540740-49-6 Usage
Uses
Used in Pharmaceutical Industry:
1-(Phenylsulfonyl)-1H-indole-3-carboxamide is used as an anticancer agent for its ability to inhibit the MAPK signaling pathway. This inhibition blocks the activation of certain kinases within the pathway, ultimately leading to the suppression of tumor cell growth and survival. TAK-632 has demonstrated promising results in preclinical studies and is being further investigated for its potential as a targeted therapy for cancer treatment.
Used in Cancer Research:
1-(Phenylsulfonyl)-1H-indole-3-carboxamide is used as a research tool for studying the role of the MAPK signaling pathway in cancer development and progression. Its ability to inhibit this pathway makes it a valuable compound for understanding the underlying mechanisms of cancer and for identifying potential therapeutic targets.
Used in Drug Development:
TAK-632 is used in the development of novel cancer treatments, particularly for cancers driven by aberrant MAPK pathway signaling, such as melanoma and colorectal cancer. Its potential as a targeted therapy is being explored, with the aim of improving patient outcomes and reducing side effects associated with conventional chemotherapy.
Check Digit Verification of cas no
The CAS Registry Mumber 540740-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,0,7,4 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 540740-49:
(8*5)+(7*4)+(6*0)+(5*7)+(4*4)+(3*0)+(2*4)+(1*9)=136
136 % 10 = 6
So 540740-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H12N2O3S/c16-15(18)13-10-17(14-9-5-4-8-12(13)14)21(19,20)11-6-2-1-3-7-11/h1-10H,(H2,16,18)
540740-49-6Relevant academic research and scientific papers
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies
Silvestri, Romano,De Martino, Gabriella,La Regina, Giuseppe,Artico, Marino,Massa, Silvio,Vargiu, Laura,Mura, Massimo,Loi, Anna Giulia,Marceddu, Tiziana,La Colla, Paolo
, p. 2482 - 2493 (2007/10/03)
The potent anti-HIV-1 activities of L-737,126 (2) and PAS sulfones prompted us to design and test against HIV-1 in acutely infected MT-4 cells a number of novel 1- and 3-benzenesulfonylindoles. Indoles belonging to the 1-benzenesulfonyl series were found
