540740-49-6 Usage
General Description
1-(Phenylsulfonyl)-1H-indole-3-carboxamide, also known as TAK-632, is a chemical compound with the molecular formula C15H12N2O3S. It is a small molecule inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a crucial role in cell proliferation, differentiation, and survival. TAK-632 has been studied for its potential therapeutic effects in treating various types of cancer, particularly those driven by aberrant MAPK pathway signaling, such as melanoma and colorectal cancer. It is believed to exert its anti-cancer effects by blocking the activation of certain kinases within the MAPK pathway, ultimately leading to inhibition of tumor cell growth and survival. TAK-632 has demonstrated promising results in preclinical studies and is being further investigated for its potential as a targeted therapy for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 540740-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,0,7,4 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 540740-49:
(8*5)+(7*4)+(6*0)+(5*7)+(4*4)+(3*0)+(2*4)+(1*9)=136
136 % 10 = 6
So 540740-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H12N2O3S/c16-15(18)13-10-17(14-9-5-4-8-12(13)14)21(19,20)11-6-2-1-3-7-11/h1-10H,(H2,16,18)
540740-49-6Relevant articles and documents
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies
Silvestri, Romano,De Martino, Gabriella,La Regina, Giuseppe,Artico, Marino,Massa, Silvio,Vargiu, Laura,Mura, Massimo,Loi, Anna Giulia,Marceddu, Tiziana,La Colla, Paolo
, p. 2482 - 2493 (2007/10/03)
The potent anti-HIV-1 activities of L-737,126 (2) and PAS sulfones prompted us to design and test against HIV-1 in acutely infected MT-4 cells a number of novel 1- and 3-benzenesulfonylindoles. Indoles belonging to the 1-benzenesulfonyl series were found