540740-61-2Relevant academic research and scientific papers
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement
Li, Xiao,Gao, Ping,Huang, Boshi,Zhou, Zhongxia,Yu, Zhao,Yuan, Zheng,Liu, Huiqing,Pannecouque, Christophe,Daelemans, Dirk,De Clercq, Erik,Zhan, Peng,Liu, Xinyong
, p. 190 - 201 (2016/10/25)
To further explore the chemical space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing N-substituted piperidine at indole-2-carboxamide were identified as potent HIV NNRTIs by structure-
Indolylaryl-sulfone derivative, as well as preparation method and application thereof
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Paragraph 0046; 0047, (2018/02/04)
The invention discloses an indolylaryl-sulfone derivative shown in general formula I, a pharmaceutically acceptable salt, ester or prodrug and preparation method thereof and application of a composition containing one or more such compounds to preparation of a medicament for preventing and treating HIV (human immunodeficiency virus) infection. The formula is shown in the description.
Indolylarylsulfones bearing natural and unnatural amino acids. discovery of potent inhibitors of hiv-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie b4 virus
Piscitelli, Francesco,Coluccia, Antonio,Brancale, Andrea,La Regina, Giuseppe,Sansone, Anna,Giordano, Cesare,Balzarini, Jan,Maga, Giovanni,Zanoli, Samantha,Samuele, Alberta,Cirilli, Roberto,La Torre, Francesco,Lavecchia, Antonio,Novellino, Ettore,Silvestri, Romano
scheme or table, p. 1922 - 1934 (2009/12/31)
New potent indolylarylsulfone (IAS) HIV-1 NNRTIs were obtained by coupling natural and unnatural amino acids to the 2-carboxamide and introducing different electron-withdrawing substituents at position 4 and 5 of the indole nucleus. The new IASs inhibited
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies
Silvestri, Romano,De Martino, Gabriella,La Regina, Giuseppe,Artico, Marino,Massa, Silvio,Vargiu, Laura,Mura, Massimo,Loi, Anna Giulia,Marceddu, Tiziana,La Colla, Paolo
, p. 2482 - 2493 (2007/10/03)
The potent anti-HIV-1 activities of L-737,126 (2) and PAS sulfones prompted us to design and test against HIV-1 in acutely infected MT-4 cells a number of novel 1- and 3-benzenesulfonylindoles. Indoles belonging to the 1-benzenesulfonyl series were found
