54078-45-4Relevant academic research and scientific papers
Stereochemical Studies on Some vic-Bisphosphonates
Blackburn, G. Michael,Forster, Alan R.,Guo, Mao-Jun,Taylor, Graham E.
, p. 2867 - 2872 (2007/10/02)
The erythro- and racemic threo-forms of tetramethyl 1,2-dihydroxyethane-1,2-diylbisphosphonate have been identified and characterised by NMR analysis of their 2-ethoxy-1,3-dioxolane derivatives and by their independent conversion into tetramethyl cis- and trans-ethene-1,2-diylbisphosphonates respectively.Optimal conditions for the partial cis-reduction of tetraethyl ethyne-1,2-diylbisphosphonate have been identified.NMR data for the AA'XX' spectra of this range of two-carbon gem- and vic-bisphosphonates are provided and discussed.
