540798-46-7Relevant academic research and scientific papers
Titanium-catalyzed stereoselective geminal heterodihalogenation of β-ketoesters
Frantz, Richard,Hintermann, Lukas,Perseghini, Mauro,Broggini, Diego,Togni, Antonio
, p. 1709 - 1712 (2003)
(Matrix presented) β-Ketoesters can be effectively monofluorinated with F-TEDA using CpTiCl3 as a catalyst. With the use of this catalyst, the extent of the competing difluorination does not reach 10%. [TiCl2(TADDOLato)] complexes catalyze the one-pot enantioselective heterodihalogenation of β-ketoesters with F-TEDA and NCS to afford α-chloro-α-fluoro-β-ketoesters in moderate to good yields. The sequence of addition of the halogenating agents determines the sense of chiral induction.
