54082-69-8

Basic information

• Product Name: alpha-Irone
• Synonyms: 2,6-cis-(2(1),2(2))-alpha-Ionone, cis-; 3-Buten-2-one, 4-(2,5,6,6-tetramethyl-2-cyclohexen-1-yl)-; 4-(2,5,6,6-Tetramethyl-2-cyclohexen-1-yl)-3-buten-2-one; 5-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-4-penten-3-one; 6-Methyl-alpha-ionone; AI3-36190; BRN 1343498; Cyclocitrylidenebutanone, alpha-; Cyclocitrylidenemethyl ethyl ketone, alpha-; EINECS 201-219-6; FEMA No. 2597; Methyl alpha-ionone; Methyl-alpha-ionone; alpha-Inone, methyl- (6CI); alpha-Ionone, methyl-; 4-(2,5,6,6-Tetramethylcyclohex-2-enyl)but-3-en-2-one; Irone, alpha-; 4-(2,5,6,6-tetramethylcyclohex-2-en-1-yl)but-3-en-2-one; (3E)-4-[(1S,5R)-2,5,6,6-tetramethylcyclohex-2-en-1-yl]but-3-en-2-one; (3E)-4-(2,5,6,6-tetramethylcyclohex-2-en-1-yl)but-3-en-2-one
• CAS NO: 54082-69-8
• Molecular Formula: C₁₄H₂₂O
• Molecular Weight: 206.3239
• EINECS: 201-219-6
• Mol File: 54082-69-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 278.7°C at 760 mmHg
• Flash Point: 118.4°C
• Density: 0.914g/cm³
• Vapor Pressure: 0.00419mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: alpha-Irone(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-Irone(54082-69-8)
• EPA Substance Registry System: alpha-Irone(54082-69-8)

Safety Data

• Hazardous Substances Data: 54082-69-8(Hazardous Substances Data)

Upstream product

• 52612-58-5 (3E,5E)-6,9,10-Trimethyl-undeca-3,5,9-trien-2-one 
• 917-54-4 methyllithium 
• 107953-24-2 (E/Z)-(4R,6S)-(1,4,5,5-Tetramethyl-1-cyclohexen-6-yl)acrylonitrile 
• 140632-38-8 (+)-(3R,7S)-4,7,8,8-tetramethyl-1-oxaspiro<2.5>oct-4-ene 
• 67-64-1 acetone 
• 153061-00-8 (-)-(5S)-2,5,6,6-tetramethylcyclohex-1-ene-1-carbaldehyde 
• 58307-67-8 3,6,7-trimethyl-6-octen-1-en-3-ol 
• 3899-32-9 (E)-3,6,7-trimethylocta-2,6-dien-1-ol 
• 142787-74-4 (3E)-6,9,10-trimethylundeca-3,5,8-trien-2-one 
• 107815-27-0 3,3,4-trimethylcyclohexanone 
• 10463-42-0 3,4-dimethyl-cyclohex-2-enone 
• 70092-37-4 1,3,3,4-tetramethylcyclohex-1-ene 
• 1423-60-5 methyl ethynyl ketone 
• 687-68-3 5,6-dimethyl-5-hepten-2-one 

Downstream Products

• 89888-03-9 (E,2S,6R)-(-)-cis-α-irone 
• 62430-55-1 optically inactive 2,2'-dimethyl-ε,ε-carotene 
• 27687-81-6 (+/-)-4t-(2,5,6,6-tetramethyl-cyclohex-1-enyl)-but-3-en-2-one-(2,4-dinitro-phenylhydrazone); (+/-)-trans-β-iron-(2,4-dinitro-phenylhydrazone) 
• 16769-63-4 (+/-)-4-(2,2,3t,6c-tetramethyl-cyclohex-r-yl)-butan-2-one semicarbazone 

Relevant articles and documents

Enantioselective divergent synthesis of (-)-cis-a- And (-)-cis-g-irone by using wilkinson's catalyst

A simple, efficient synthesis is reported for (-)-cis-a-and (-)-cis-g-irone, two precious constituents of iris oils, in ≥99% diastereomeric and enantioselective ratios. The two routes diverge from a common intermediate prepared from (-)-epoxygeraniol. Of general interest in this approach is the installation of the enone moiety of irones through a NHC-AuI-catalyzed Meyer-Schuster-like rearrangement of a propargylic benzoate and the use of Wilkinson's catalyst for the stereoselective hydrogenation of a prostereogenic exocyclic double bond to secure the critical cis stereochemistry of the alkyl groups at C2 and C6 of the irones. The stereochemical aspects of this reaction are rationally supported by DFT calculation of the conformers of the substrates undergoing the hydrogenation and by a modeling study of the geometry of the rhodium ν2 complexes involved in the diastereodifferentiation of the double bond faces. Thus, computational investigation of the ν2 intermediates formed in the catalytic cycle of prostereogenic alkene hydrogenation by using Wilkinson's catalyst could be highly predictive of the stereochemistry of the products.

Cyclization of cis- and trans-6,7-trans-8,9-Pseudoirones in Super Acids

Stable cations from 2,3,6-trimethyl-6Z,E,8E-undecadien-10-ones (cis- and trans-pseudoirones) were generated in the HSO3F-SO2FCl system fot the first time.Configuration of the conjugated C6=C7 double bond in these ketones substantiall

An Alternative Access to (+/-)-α-Irones and (+/-)-β-Irone via Acid-Mediated Cyclisation

Acid-mediated cyclisation of trienone 8, readily available from 2,3-dimethylbutanal (1; five steps: 47percent yield), using fluorosulfonic acid (6.8 mol-equiv.) in 2-nitropropane at -70 deg, afforded a 14:9:1 mixture (70percent yield) of (+/-)-cis-α-irone