5410-79-7

Usage

Uses

Used in Research and Development:
(4-hydroxy-3-nitrophenyl)arsonous acid is used as a chemical compound in research and development for its unique properties and potential applications in various fields. However, due to its high toxicity, it is handled with extreme care and its use is restricted.
Used in Chemical Analysis:
In chemical analysis, (4-hydroxy-3-nitrophenyl)arsonous acid may be used as a reagent or in the synthesis of other compounds. Its application is limited due to its toxicity, and it is essential to follow strict safety protocols when working with (4-hydroxy-3-nitrophenyl)arsonous acid.
Used in Environmental Monitoring:
(4-hydroxy-3-nitrophenyl)arsonous acid can be used in environmental monitoring to detect and measure the presence of arsenic and other toxic elements in the environment. This is crucial for assessing the potential health risks and implementing appropriate safety measures.

Upstream product

• 121-19-7 roxarsone 

Relevant academic research and scientific papers

CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor

The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.

Methylated Phenylarsenical Metabolites Discovered in Chicken Liver

We report the discovery of three toxicologically relevant methylated phenylarsenical metabolites in the liver of chickens fed 3-nitro-4-hydroxyphenylarsonic acid (ROX), a feed additive in poultry production that is still in use in several countries. Methyl-3-nitro-4-hydroxyphenylarsonic acid (methyl-ROX), methyl-3-amino-4-hydroxyphenylarsonic acid (methyl-3-AHPAA), and methyl-3-acetamido-4-hydroxyphenylarsonic acid (or methyl-N-acetyl-ROX, methyl-N-AHPAA) were identified in such chicken livers, and the concentration of methyl-ROX was as high as 90 μg kg?1, even after a five-day clearance period. The formation of these newly discovered methylated metabolites from reactions involving trivalent phenylarsonous acid substrates, S-adenosylmethionine, and the arsenic (+3 oxidation state) methyltransferase enzyme As3MT suggests that these compounds are formed by addition of a methyl group to a trivalent phenylarsenical substrate in an enzymatic process. The IC50 values of the trivalent phenylarsenical compounds were 300–30 000 times lower than those of the pentavalent phenylarsenicals.