54125-08-5Relevant academic research and scientific papers
Evaluation of alkene isomerization as a trigger for enediyne activation
Semmelhack,Sarpong, Richmond,Bergman, Jeffrey,Ho, Douglas M.
, p. 541 - 544 (2007/10/03)
The concept of non-conjugated-to-conjugated double bond isomerization as a triggering mechanism for a calicheamicin model was tested. A bicyclo[7.3.1] enediyne framework was prepared with a bridgehead double bond and an acetonyl side chain. Base-promoted exchange failed to produce the conjugated isomer. Computational analysis suggested that additional conjugating groups would favor the isomerization, but experiment proved that not to be correct.
Lewis acid catalyzed procedure for selective conversion of the carbocyclic Diels-Alder adducts of Danishefsky's diene to 2-cyclohexenones and its extension to their one-pot syntheses
Inokuchi,Okano,Miyamoto,Bte Madon,Takagi
, p. 1549 - 1552 (2007/10/03)
Conversion of the carbocyclic Diels-Alder adducts of 4-methoxy-2-trimethylsiloxy-1,3-butadiene (Danishefsky's diene), prepared by heating, to the corresponding 2-cyclohexenones was performed cleanly by use of Lewis acids such as Yb(OTf)3 and Bu
