54130-36-8

Basic information

• Product Name: N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE
• Synonyms: N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE;PROSTAGLANDIN F2ALPHA ETHYL AMIDE;PGF2ALPHA-NET;Prostaglandin F2α ethyl amide;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
• CAS NO: 54130-36-8
• Molecular Formula: C22H39NO4
• Molecular Weight: 381.55
• Mol File: 54130-36-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE(54130-36-8)
• EPA Substance Registry System: N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE(54130-36-8)

Safety Data

• Hazardous Substances Data: 54130-36-8(Hazardous Substances Data)

Usage

Description

Prostaglandin F2α ethyl amide (PGF2α-NEt) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.