5414-19-7Relevant academic research and scientific papers
Solubility of 3,3′-(Oxidi-2,1-ethanediyl)bis[1-methyl-imidazolium] Dihexafluorophosphate in Water, Methanol, Ethanol, Acetone, and Acetonitrile and Binary Mixtures (Water + DMF) from (283.00 to 323.00) K
Guo, Jia-Rong,Xu, Bin,Wang, Yan,Zhuang, Ling-Hua,Wang, Guo-Wei
, p. 1091 - 1097 (2015)
3,3′-(Oxidi-2,1-ethanediyl)bis[1-methyl-imidazolium] dihexafluorophosphate ([C4O(mim)2][PF6]2) was synthesized and confirmed with 1H NMR and FT-IR. The thermal stability of [C4O(mim)2][PF6]2 was studied with differential scanning calorimetry and thermogravimetric analyses. Using the dynamic method, the solubility of [C4O(mim)2][PF6]2 in five different pure solvents (water, methanol, ethanol, acetone, and acetonitrile) and binary mixtures (water + DMF) was measured at the temperature range from (283.00 to 323.00 K) at atmospheric pressure. The solubility of [C4O(mim)2][PF6]2 in those selected solvents increased with increasing temperature and DMF contents, but the rate of solubility is different. The experimental data were correlated with the modified Apelblat equation. Also, the solubility of [C4O(mim)2][PF6]2 and [C6O2(mim)2][PF6]2 was been compared in the same solvent. (Graphical Presented).
Synthesis of new heterocyclic dehydroabietylamine derivatives and their biological activity
Kovaleva, Kseniya S.,Yarovaya, Olga I.,Shernyukov, Andrey V.,Zarubaev, Vladimir V.,Shtro, Anna A.,Orshanskaya, Yana R.,Salakhutdinov, Nariman F.
, p. 364 - 370 (2017)
(figure presented) New derivatives of dehydroabietylamine were obtained by transformation of primary amino group to pyrrolidine, piperidine, azepane, morpholine, isoindoline, and pyrrole heterocycles. The obtained compounds were tested for antiviral activity against influenza A/California/07/09 (H1N1)pdm09 strain, as well as the activity against some types of bacteria and fungi.
COMPOUND, DECORATIVE MATERIAL, DECORATED ARTICLE, AND INK COMPOSITION
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Paragraph 0105; 0114-0116; 0130-0132, (2020/03/27)
To provide a compound exhibiting golden glossiness and providing a film having flexibility.SOLUTION: There is provided a compound represented by the formula (1). Rand Rare each independently a substituted or unsubstituted C1 to 12 alkyl group, -(CH)-COO-R, -(CH)-O-R, -(CH)-CONH-R, -(CH)-CONH-(CH)-OH or the like; Rto Rare each independently a C1 to 6 alkyl group; nis an integer of 2 to 10; and mto mare integer of 1 to 6.SELECTED DRAWING: None
Compound, conjugate, kit, and application of kit in detection of estradiol
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Paragraph 0096; 0103; 0104, (2018/03/26)
The invention discloses a compound, a conjugate, a kit for detecting estradiol, and an application of the kit for detecting the estradiol in detection of the estradiol. The compound has a structure shown as a formula (1), wherein the L represents a connecting arm, the R, R, R and R are respectively independently a hydrogen group, a hydroxyl group, an alkyl of C, an alkoxy of C, an alkenyl of C or an alkynyl of C. The compound disclosed by the invention can be used for accurately detecting estradiol.
Double (2-haloethyl) ether synthesis method
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Paragraph 0032-0033, (2017/02/24)
The invention relates to the synthesis of fine chemical intermediates, in particular to a synthesis method of di(2-halogenated ethyl) ether. According to the synthesis method, 1,4-thioxane-1,1-dioxo and a hydrogen halide water solution react with each other to obtain the target product, namely di(2-halogenated ethyl) ether. The synthesis method is simple and convenient in technical route, good in selectivity, high in yield, less in pollution and simple in post-processing, conforms to the tendency of the green chemical industry nowadays, and has great industrial value.
A delocalizable cationic headgroup together with an oligo-oxyethylene spacer in gemini cationic lipids improves their biological activity as vectors of plasmid DNA
Kumar, Krishan,Barrn-Berdn, Ana L.,Datta, Sougata,Muoz-beda, Mnica,Aicart-Ramos, Clara,Kondaiah, Paturu,Junquera, Elena,Bhattacharya, Santanu,Aicart, Emilio
, p. 1495 - 1506 (2015/03/04)
Lipoplex nano-aggregates constituted of plasmid DNA (pDNA) pEGFP-C3 and mixed cationic liposomes, consisting of several percentages of a gemini cationic lipid (GCL) of the 1,2-bis(hexadecyl imidazolium) oxyethylene series, referred to as (C16Im)2(C2O)n, with oxyethylene spacers (n = 1, 2 or 3) between the imidazolium cationic groups and the DOPE zwitterionic helper lipid, have been characterized by various biophysical and biological approaches carried out at several GCL compositions (α), and either the mass or the effective charge ratio of the lipoplex. The electrochemical study by ζ-potential confirms that the three GCLs yield a 10% lower effective charge than the nominal one, while compacted pDNA yields only a 25% effective negative charge. The SAXS study reveals, irrespective of the spacer length (n) and effective charge ratio (ρeff), the presence of two lamellar structures, i.e., one (Lα,main) in the whole GCL composition and another (Lα,DOPE,rich) with higher periodicity values that coexists with the previous one at low GCL composition (α = 0.2). The cryo-TEM analysis shows two types of multilamellar structures consisting of cationic lipidic bilayers with pDNA sandwiched between them: a cluster-type (C-type) at low α = 0.2 and a fingerprint-type (FP-type) at α ≥ 0.5, both with similar interlamellar spacing (d) in agreement with the Lα,main structure determined by SAXS. Transfection efficacies (TEs) of each lipid mixture were determined in four different cell lines (HEK293T, HeLa, Caco-2 and A549) at several α and ρeff values in the absence and presence of serum (FBS). The optimized formulations (α = 0.2 and ρeff = 2.0) substantially transfect cells much better than a commercial transfection reagent, Lipofectamine 2000 and previously studied efficient lipoplexes containing other cationic head groups or spacers both in the absence and presence of serum. The activity of optimized formulations may be attributed to the combination of several factors, such as: (a) the fusogenic character of DOPE which results in higher fluidity of the lipoplexes at α = 0.2, (b) the coexistence of two lamellar structures at α = 0.2 that synergizes the TE of these lipid vectors, and mainly (c) the higher biocompatibility of the GCLs reported in this work due to the presence of two imidazolium cationic groups together with an oligo-oxyethylene spacer. The length of the spacer in the GCL seems to have less impact, although (C16Im)2(C2O)n/DOPE-pDNA lipoplexes with n = 1 and 3 show higher gene transfection than n = 2. All the optimum formulations reported herein are all highly efficient with negligible levels of toxicity, and thus, may be considered as very promising gene vectors for in vivo applications. This journal is
Cationic gemini lipids containing polyoxyethylene spacers as improved transfecting agents of plasmid DNA in cancer cells
Barran-Berdon, Ana L.,Misra, Santosh K.,Datta, Sougata,Munoz-Ubeda, Monica,Kondaiah, Paturu,Junquera, Elena,Bhattacharya, Santanu,Aicart, Emilio
supporting information, p. 4640 - 4652 (2014/07/21)
Lipoplex nano-aggregates have been analyzed through biophysical characterization (electrostatics, structure, size and morphology), and biological studies (transfection efficiency and cell viability) in five cancer cell lines. Lipoplexes were prepared from pEGFP-C3 plasmid DNA (pDNA) and mixed liposomes, constituted by a zwitterionic lipid (DOPE) and a gemini cationic lipid (GCL) synthesized in this work, [bis(hexadecyl dimethyl ammonium) oxyethylene], referred to as (C16Am)2(C2O) n, (where n is the oxyethylene spacer length, n = 1, 2 or 3, between the ammonium heads). Cryo-TEM micrographs show nano-aggregates with two multilamellar structures, a cluster-type (at low-to-medium GCL composition) and a fingerprint-type that coexists with the cluster-type at medium GCL composition and appears alone at high GCL composition. SAXS diffractograms show that these lipoplexes present three lamellar structures, two of them coexisting at low and high GCL composition. The optimized transfection efficiency (TE) of pDNA was higher for lipoplexes containing GCLs with a longer (n = 3) or shorter (n = 1) polyoxyethylene spacer, at high GCL composition (α = 0.7) with low charge ratio (ρeff = 2). In the all cancer cell lines studied, the TE of the optimized formulations was much better than those of both lipofectamine 2000 and lipoplexes with GCLs of the bis(hexadecyl dimethyl ammonium) alkane series recently reported. Probably, (a) the coexistence of two lamellar structures at high GCL composition synergizes the TE of these lipid vectors, (b) the orientation of the polyoxyethylene region in (C16Am) 2(C2O)3/DOPE may occur in such a way that the spacing between two cationic heads becomes smaller than that in (C 16Am)2(C2O)2/DOPE which is poor in terms of TE, and (c) the synergistic interactions between serum proteins and (C16Am)2(C2O)n/DOPE-pDNA lipoplexes containing a polyoxyethylene spacer improve TE, especially at high GCL content. Lipoplexes studied here show very low levels of toxicity, which confirm them as improved vectors of pDNA in gene therapy.
Determination of micellar aggregation numbers of gemini surfactant in aqueous solution by steady-state fluorescence quenching method
Jie, Ni Ren,Ling, Wang Ya,Yu, Huang,Cheng, Yao
experimental part, p. 5011 - 5014 (2012/10/08)
A new kind of Gemini surfactant synthesized from the intermediate 1-bromo-2-(2-bromoethoxy)ethane and dodecyl dimethyl amine by using isopropanol as solvent. The critical micellar concentration (CMC) value of Gemini 12-Y-12 determined by Steady-state fluorescence quenching (SSFQ) method is basically in agreement with the value by surface tension method. The micellar aggregation numbers (Nagg) of this surfantant are essentially constant when the concentrations of the quencher were selected in 2.0 × 10-4-5.0 × 10-4 mol L-1. The Nagg of the Gemini surfactant increases linearly with the increase of surfactant concentration in the range of 4-9 times of critical micellar concentration and critical micellar aggregation numbers obtained by extrapolation method is 13.2.
Spectroscopic studies of the interaction between methyl orange and gemini surfactant
Jia,Gong,Ni,Su,Yao
scheme or table, p. 729 - 732 (2012/01/02)
The influence of two kinds of cationic surfactants on spectral properties of methyl orange in aqueous solutions has been investigated by means of UV-vis spectroscopy in various pH values and concentration range. For the Gemini14-methyl orange (MO) solutions, a hyperchromic shift was observed from 509-403 nm with the decrease of spectra absorption by increasing the pH values. Spectral behaviour of dye-surfactant solutions with varying concentrations of surfactants confirmed that electrostatic hydrophobic interactions between dye and surfactant played an important role. An H-type aggregation appeared in the concentration ratio 1:2 for Gemini14 and methyl orange, but in the CTAB solutions, the ratio was 1:1. The initial decrease of the absorbance resulted from dye-surfactant complex formation. It can be concluded that the amount of the cationic groups plays an important role in the complex formation.
A mild synthesis of unsymmetrical bisalkoxysilanes through catalyzed alcoholysis of hydridosilanes containing C-C multiple bonds and aryl halides
Scott, Colleen N.,Wilcox, Craig S.
experimental part, p. 253 - 256 (2010/04/06)
(Chemical Equation Presented) The synthesis of unsymmetrical bisalkoxysilanes containing unsaturated C-C bonds and alkyl and aryl bromides has been developed. This method is a modification of our previously reported two-step procedure that utilizes readily available catalysts (rhodium acetate dimer and manganese pentacarbonyl bromide) under mild neutral aprotic conditions. Good to moderate yields of the products were obtained in a short period. In this two-step synthesis, unsymmetrical bisalkoxysilanes with groups that can be further functionalized can be prepared effectively without the need to isolate the intermediates. 2009 American Chemical Society.
