54143-57-6

Basic information

• Product Name: Metoclopramide hydrochloride
• Synonyms: Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate;Metoclopramide monohydrochloride monohydrate;Metoclopramide Hydrochloride (500 mg);Annavar;MetoclopraMide Hydrochloride, USP;MetoclopraMide HCI;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride monohydrate;Metoclopramide (hydrochloride hydrate)
• CAS NO: 54143-57-6
• Molecular Formula: C14H22ClN3O2.ClH
• Molecular Weight: 336.26
• EINECS: 230-634-5
• Product Categories: Steroid and Hormone;API
• Mol File: 54143-57-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 182.5-184°
• Boiling Point: 504.6 °C at 760 mmHg
• Flash Point: 259 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• Water Solubility: It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane.
• Sensitive: Light Sensitive
• CAS DataBase Reference: Metoclopramide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Metoclopramide hydrochloride(54143-57-6)
• EPA Substance Registry System: Metoclopramide hydrochloride(54143-57-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 54143-57-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 54143-57-6 differently. You can refer to the following data:
1. Metoclopramide Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence techniques.
2. Dopamine receptor antagonist; antiemetic.

Indications

Metoclopramide (Reglan) stimulates upper GI tract motility and has both central and peripheral actions. Centrally, it is a dopamine antagonist, an action that is important both for its often desirable antiemetic effect and other less desirable effects. Peripherally, it stimulates the release of intrinsic postganglionic stores of acetylcholine and sensitizes the gastric smooth muscle to muscarinic stimulation. The ability of metoclopramide to antagonize the inhibitory neurotransmitter effect of dopamine on the GI tract results in increased gastric contraction and enhanced gastric emptying and small bowel transit.

Definition

ChEBI: A hydrate that is the monohydrate form of metoclopramide monohydrochloride.

Therapeutic Function

Antiemetic

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Metoclopramide Hydrochloride is an antiemetic drug and is generally used for the treatment of gastrointestinal disorders. It can also exhibit sedative, extrapyrimidal, and prolactin secretion stimulation actions.

Mechanism of action

Metoclopramide is rapidly absorbed following an oral dose in a patient with intact gastric emptying. Peak plasma concentration is achieved within 40 to 120 minutes. With normal renal function, plasma half-life is about 4 hours.About 20% of an oral dose is eliminated unchanged in the urine, while 60% is eliminated as sulfate or glucuronide conjugates.

Clinical Use

Improved gastric emptying will frequently alleviate symptoms in patients with diabetic, postoperative, or idiopathic gastroparesis. Since metoclopramide also can decrease the acid reflux into the esophagus that results from slowed gastric emptying or lower esophageal sphincter pressure, the drug can be used as an adjunct in the treatment of reflux esophagitis.

Side effects

Side effects include fatigue, insomnia, and altered motor coordination. Parkinsonian side effects and acute dystonic reactions also have been reported. Metoclopramide stimulates prolactin secretion, which can cause galactorrhea and menstrual disorders. Extrapyramidal side effects seen following administration of the phenothiazines, thioxanthenes, and butyrophenones may be accentuated by metoclopramide.