54157-02-7Relevant academic research and scientific papers
Photocatalyst-Free, Visible-Light-Mediated C(sp3)-H Arylation of Amides via a Solvent-Caged EDA Complex
Kaur, Jaspreet,Shahin, Ahmed,Barham, Joshua P.
supporting information, p. 2002 - 2006 (2021/03/08)
A photocatalyst-free and mild visible light photochemical procedure for C(sp3)-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxi
Friedel-Crafts amidoalkylation via thermolysis and oxidative photocatalysis
Dai, Chunhui,Meschini, Francesco,Narayanam, Jagan M. R.,Stephenson, Corey R. J.
experimental part, p. 4425 - 4431 (2012/06/30)
Friedel-Crafts amidoalkylation was achieved by oxidation of dialkylamides using persulfate (S2O82-) in the presence of the visible light catalyst, Ru(bpy)3Cl2, at room temperature, via a reactive N-acyliminium intermediate. Alternatively, mild heating of the dialkylamides and persulfate afforded a metal and Lewis acid-free Friedel-Crafts amidoalkylation. Alcohols and electron-rich arenes served as effective nucleophiles, forming new C-O or C-C bonds. In general, photocatalysis provided higher yields and better selectivities.
