54164-07-7

Usage

Uses

Used in Pharmaceutical Research:
S-α-APA is utilized as a research chemical for the development of novel psychoactive substances and understanding the mechanisms of action related to stimulant and entactogen drugs. Its potent effects on neurotransmitter release make it a valuable compound for studying the neurochemical basis of mood, energy, and alertness.
Used in Drug Abuse Prevention and Treatment:
As a compound linked to drug abuse, S-α-APA is also used in the development of strategies for prevention and treatment of substance abuse disorders. Understanding its effects on the brain and the potential for dependence can inform the creation of educational programs, policy, and therapeutic interventions to address the challenges posed by synthetic cathinones.
Used in Toxicology and Regulatory Science:
S-α-APA is employed in toxicological research to evaluate the safety and potential hazards associated with its use. This information is crucial for regulatory agencies in establishing guidelines and restrictions to protect public health and mitigate the risks of abuse and dependence.
Used in Forensic Science:
In forensic science, S-α-APA is utilized as a marker in the detection and identification of synthetic cathinones in cases involving drug-related crimes. Its unique chemical properties facilitate the analysis of evidence and contribute to the investigation and prosecution of drug-related offenses.
Used in Analytical Chemistry:
S-α-APA serves as a reference compound in the development and validation of analytical methods for the detection and quantification of synthetic cathinones in various matrices, such as biological samples, environmental samples, and seized drug materials. This application aids in the enforcement of drug regulations and the monitoring of emerging trends in the drug market.

Upstream product

• 130013-62-6 (S)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate 
• 13734-41-3 t-Boc-L-valine 

Downstream Products

• 56415-48-6 (1S,2R)-Cyclohexane-1,2-dicarboxylic acid 1-hydroxyamide 2-{[(R)-2-methyl-1-(pyrrolidine-1-carbonyl)-propyl]-amide} 
• 863555-44-6 Boc-L-Phe-L-Val-N-pyrrolidinyl 

Relevant academic research and scientific papers

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure-activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrate the brain.

PHOSPHOROAMIDE COMPOUND, METHOD FOR PRODUCING THE SAME, LIGAND, COMPLEX, CATALYST, AND METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL

Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a ca

Design of an organocatalyst for the enantioselective Diels-Alder reaction with α-acyloxyacroleins

We have realized the first enantioselective organocatalytic Diels-Alder reaction between α-substituted acroleins, such as α-acyloxyacroleins, and not only cyclic but also acyclic dienes. α-Acyloxyacroleins are useful as synthetic equivalents of α-haloacro