54164-82-8Relevant academic research and scientific papers
Enantio- and stereospecific syntheses of 15(R)-Me-PGD2, a potent and selective DP2-receptor agonist
Patel, Pranav,Lee, Gue-Jae,Kim, Seongjin,Grant, Gail E.,Powell, William S.,Rokach, Joshua
experimental part, p. 7213 - 7218 (2009/05/26)
(Chemical Equation Presented) The first total synthesis of 15(R)-Me-PGD2 3 is reported. The synthesis is based on the enantioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction. This approach permits the introduction of a side chain with a predetermined stereogenic center into the prostanoid ring, resulting in the synthesis of 15R-methyl prostaglandin D2 and allows rapid access to other prostanoids.
