5417-21-0Relevant articles and documents
NOVEL HYDROXAMIC ACID DERIVATIVE
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Paragraph 0179-0180, (2013/03/26)
Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A
Carr, Gavin,Chung, Marco K. W.,Mauk, A. Grant,Andersen, Raymond J.
, p. 2634 - 2637 (2008/12/22)
Synthetic analogues of the sponge natural product exiguamine A (3) have been prepared and evaluated for their ability to inhibit indoleamine 2,3-dioxygenase in vitro.
153. Azomalonate Syntheses; Part II; Synthesis and Reactivity of Novel 1,2,4-Triazin-5-one Derivatives
Heckendorn, Roland
, p. 1700 - 1718 (2007/10/02)
Base treatment of azomalonates derived from N-substituted dialkyl (2-chloroacetamido)malonates results in the formation of 4-substituted alkyl 5-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylates.The same malonates coupled with diazotized 2-amino-5-chlo