5417-21-0Relevant articles and documents
NOVEL HYDROXAMIC ACID DERIVATIVE
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Paragraph 0179-0180, (2013/03/26)
Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
153. Azomalonate Syntheses; Part II; Synthesis and Reactivity of Novel 1,2,4-Triazin-5-one Derivatives
Heckendorn, Roland
, p. 1700 - 1718 (2007/10/02)
Base treatment of azomalonates derived from N-substituted dialkyl (2-chloroacetamido)malonates results in the formation of 4-substituted alkyl 5-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylates.The same malonates coupled with diazotized 2-amino-5-chlo