54184-81-5

Basic information

• Product Name: 1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI)
• Synonyms: 1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI);3-Amino-5-methyl-1H-pyrazole-4-carboxamide
• CAS NO: 54184-81-5
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.14322
• Product Categories: AMIDE
• Mol File: 54184-81-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 365°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: /
• Density: 1.426g/cm³
• Vapor Pressure: 1.62E-05mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI)(54184-81-5)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI)(54184-81-5)

Safety Data

• Hazardous Substances Data: 54184-81-5(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-4-carboxamide,3-amino-5-methyl-(9CI) is a chemical compound with the molecular formula C5H7N3O and a molecular weight of 125.13 g/mol. It is also known by its CAS number 54324-21-3 and has a melting point of 216-218°C. This chemical is a pyrazole derivative and can be used in the synthesis of other organic compounds. It is a white to off-white solid and is soluble in organic solvents such as dimethyl sulfoxide and methanol. Its primary applications include use in pharmaceutical research and as an intermediate in organic synthesis.

InChI:InChI=1/C5H8N4O/c1-2-3(5(7)10)4(6)9-8-2/h1H3,(H2,7,10)(H3,6,8,9)

Upstream product

• 62321-92-0 α-cyano-β-dimethylaminocrotonamide 
• 5453-07-6 5-amino-3-methyl-1H-pyrazole-4-carbonitrile 

Downstream Products

• 2942-47-4 3-Methyl-4-hydroxypyrazolo<3,4-d>pyrimidin 
• 127820-65-9 3-methyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine-4,6(5H,7H)-dione 
• 127820-64-8 6-bromo-3-methyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 127820-66-0 6-amino-3-methyl-1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidin-4(5H)-one 

Relevant articles and documents

PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES

Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and esters are anti-proliferative agents useful in the treatment or control of proliferative disorders such as solid tumors, in particular breast tumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosed are a composition and a unit dose formulation comprising such a compound, or a pharmaceutically-acceptable salt or ester thereof, methods for making such compounds, and methods for using such compounds, or their pharmaceutically-acceptable salts or esters, in the treatment of proliferative disorders.

Guanosine Analogues. Synthesis of Nucleosides of Certain 3-Substituted 6-Aminopyrazolopyrimidin-4(5H)-ones as Potential Immunotherapeutic Agents

Several guanosine analogues were synthesized in the pyrazolopyrimidine ring system with various substituents at the 3-position.The new analogues prepared here include the CH3 (2-amino-3-methyl-1-β-D-ribofuranosylpyrazolopyrimidin-4(5H)-one,