542-59-6

Basic information

• Product Name: 2-HYDROXYETHYL ACETATE
• Synonyms: 1,2-Ethanediol,monoacetate;1,2-ethanediolmonoacetate;2-Acetoxyethanol;2-Hydroxyethyl ester of acetic acid;2-Hydroxyethylester kyseliny octove;2-hydroxyethylesterkyselinyoctove;beta-Hydroxyethyl acetate;Glycol, monoacetate
• CAS NO: 542-59-6
• Molecular Formula: C₄H₈O₃
• Molecular Weight: 104.1
• EINECS: 208-821-8
• Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
• Mol File: 542-59-6.mol
• Article Data: 64

Chemical Properties

• Boiling Point: 182°C
• Flash Point: 102°C
• Appearance: /
• Density: 1,11 g/cm3
• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: n20/D 1.42(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.16±0.10(Predicted)
• Water Solubility: Completely miscible in water
• Merck: 14,3801
• CAS DataBase Reference: 2-HYDROXYETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYETHYL ACETATE(542-59-6)
• EPA Substance Registry System: 2-HYDROXYETHYL ACETATE(542-59-6)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-65-63-48/23/24/25-60-46-45
• Safety Statements: 26-36/37/39-45-23-53
• RTECS: KW7175000
• Hazardous Substances Data: 542-59-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid; almost odorless.Soluble in water, alcohol, ether, benzene, and toluene. Combustible.

Uses

Solvent for nitrocellulose, cellulose acetate, camphor.

General Description

Almost odorless clear colorless liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-HYDROXYETHYL ACETATE can react with oxidizing materials.

Fire Hazard

2-HYDROXYETHYL ACETATE is combustible.

Purification Methods

Dry the ester over K2CO3 (not CaCl2), and distil it. [Davis & Ross J Chem Soc 3061 1950, rate of hydrolysis: Davis & Ross J Chem Soc 2706 1951, Beilstein 2 H 141, 2 I 66, 2 II 154, 2 III 303, 2 IV 214.]

InChI:InChI=1/C4H8O3/c1-4(6)7-3-2-5/h5H,2-3H2,1H3

Upstream product

• 67-56-1 methanol 
• 111-55-7 ethylene glycol diacetate 
• 60-35-5 acetamide 
• 107-21-1 ethylene glycol 
• 141-82-2 malonic acid 
• 64-19-7 acetic acid 
• 127-08-2 potassium acetate 
• 107-06-2 1,2-dichloro-ethane 
• 497-26-7 2-methyl-1,3-dioxolane 
• 2386-26-7 ethyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 30345-49-4 tetra-n-butylphosphonium acetate 
• 4745-31-7 2-chloro-1,3,2-dioxastibolane 

Downstream Products

• 34500-18-0 2-acetoxyethyl acetoacetate 
• 110-85-0 piperazine 
• 111-55-7 ethylene glycol diacetate 
• 107-21-1 ethylene glycol 
• 84-65-1 9,10-phenanthrenequinone 
• 112607-88-2 Acetic acid 2-(anthracen-9-yloxy)-ethyl ester 
• 542-10-9 ethylidene diacetate 
• 1349701-29-6 C₁₄H₂₄O₆ 
• 42772-85-0 2-hydroxyethyl 4-methylbenzenesulfonate 
• 19859-09-7 Ethylenglycolacetattosylat 
• 22613-51-0 1-acetoxy-2-stearoyloxy-ethane 
• 927-68-4 bromoethyl acetate 
• 542-58-5 2-chloro-1-acetoxyethane 
• 78759-26-9 1-acetoxy-2-(1-phenyl-ethoxy)-ethane 

Relevant articles and documents

Evidence for the HOOO- anion in the ozonation of 1,3-dioxolanes: Hemiortho esters as the primary products

Low-temperature ozonation (-78 °C) of 2-methyl-1,3-dioxolane (1a) in acetone-d6, methyl acetate, and tert-butyl methyl ether produced both the corresponding acetal hydrotrioxide (3a, ROOOH) and the hemiortho ester (2a, ROH) in molar ratio 1:5. Both intermediates were fully characterized by 1H, 13C, and 17O NMR spectroscopy, and they both decomposed to the corresponding hydroxy ester at higher temperatures. The mechanism involving the HOOO- anion formed by the abstraction of the hydride ion by ozone to form an ion pair, R+ -OOOH, with its subsequent collapse to either the corresponding hemiortho ester (ROH) or the acetal hydrotrioxide (ROOOH) was proposed. This mechanism is supported by the PISA/B3LYP/6-311++G(3df,3pd) calculations. Copyright

MECHANISM FOR FORMATION OF ETHYLENE GLYCOL MONOACETATE FROM ETHYLENE IN ACETIC ACID SOLUTION CONTAINING LITHIUM NITRATE AND PALLADIUM ACETATE

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Catalytic Hydrogenation of Thioesters, Thiocarbamates, and Thioamides

Direct hydrogenation of thioesters with H2 provides a facile and waste-free method to access alcohols and thiols. However, no report of this reaction is documented, possibly because of the incompatibility of the generated thiol with typical hydrogenation catalysts. Here, we report an efficient and selective hydrogenation of thioesters. The reaction is catalyzed by an acridine-based ruthenium complex without additives. Various thioesters were fully hydrogenated to the corresponding alcohols and thiols with excellent tolerance for amide, ester, and carboxylic acid groups. Thiocarbamates and thioamides also undergo hydrogenation under similar conditions, substantially extending the application of hydrogenation of organosulfur compounds.

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.