54208-12-7

Upstream product

• 114-70-5 sodium phenylacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 103-82-2 phenylacetic acid 

Downstream Products

• 54208-32-1 (E)-3-(3,4-Dimethoxy-phenyl)-2-phenyl-acrylic acid methyl ester 
• 54208-44-5 (Z)-3-(3,4-Dimethoxy-phenyl)-2-phenyl-prop-2-en-1-ol 

Relevant academic research and scientific papers

Intramolecular Biaryl Oxidative Coupling of Stilbenes by Vanadium Oxytrichloride (VOCl3): Facile Synthesis of Substituted Phenanthrene Derivatives

Vanadium oxytrichloride (VOCl3) has proven to be a highly efficient reagent for intramolecular biaryl oxidative coupling reaction of electron-rich stilbenes. Accordingly, a mild and efficient route to phenanthrene derivatives from stilbenes oxy

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Synthesis and antioxidant activity of hydroxylated phenanthrenes as cis-restricted resveratrol analogues

Five hydroxylated phenanthrenes as "cis-configuration-fixed" resveratrol analogues differing in the number and position of the hydroxyl groups were designed and synthesized. Their antioxidant activity was studied by ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging, and DNA strand breakage-inhibiting assays, corresponding to their electron-donating, hydrogen-transfer and DNA-protecting abilities, respectively. In the above assays, their activity depends significantly on the number and position of the hydroxyl groups, and most of them are more effective than resveratrol. Noticeably, compound 9b (2,4,6-trihydroxyl phenanthrene) with the same hydroxyl group substitutions as resveratrol, is superior to the reference compound, highlighting the importance of extension of the conjugation over multiple aromatic-rings. Similar activity sequences were obtained in different experimental models, but the appreciable differences could contribute detailed insights into antioxidant mechanisms. Based on these results, the hydroxylated phenanthrenes may be considered as a novel type of resveratrol-directed antioxidants.