54208-22-9Relevant academic research and scientific papers
Synthesis and Evaluation of Coumarin-Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors
Rahmani-Nezhad, Samira,Khosravani, Leila,Saeedi, Mina,Divsalar, Kouros,Firoozpour, Loghman,Pourshojaei, Yaghoub,Sarrafi, Yaghoub,Nadri, Hamid,Moradi, Alireza,Mahdavi, Mohammad,Shafiee, Abbas,Foroumadi, Alireza
supporting information, p. 751 - 759 (2015/10/29)
A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities. GRAPHICAL ABSTRACT.
3-Arylcoumarins: Synthesis and potent anti-inflammatory activity
Pu, Wenchen,Lin, Yuan,Zhang, Jianshuo,Wang, Fei,Wang, Chun,Zhang, Guolin
supporting information, p. 5432 - 5434 (2015/01/08)
Chronic inflammation is the persistent and excessive immune response and can lead to a variety of diseases. Aiming to discover new compounds with anti-inflammatory activity, we report herein the synthesis and biological evaluation of 3-arylcoumarins. Thirty five 3-arylcoumarins were prepared through Perkin condensation and further acid-promoted hydrolysis if necessary. In lipopolysaccharide-activated mouse macrophage RAW264.7 cells, 6,8-dichloro-3-(2-methoxyphenyl)coumarin (16) and 6-bromo-8-methoxy-3-(3-methoxyphenyl)coumarin (25) exhibited nitric oxide production inhibitory activity with the IC50 values of 8.5 μM and 6.9 μM, respectively, providing a pharmacological potential as anti-inflammatory agents.
(Z)-2-acetoxy-3,3′,4′-trimethoxystilbene
Li, Shiming,Lundquist, Knut,Stomberg, Rolf
, p. 3118 - 3121 (2007/10/03)
The crystal structure determination demonstrates unambiguously that the title compound, 2-[(Z)-3,4-dimethoxyphenylethenyl]-6-methoxypheenyl acetate, C19H20O5, has the Z configuration. The title compound was prepared by decarboxylation of (E)-3-(2-acetoxy-3-methoxyphenyl)-2-(3,4-dimethoxyphenyl)propenoic acid; this compound was in turn obtained by condensation of 2-acetoxy-3-methoxybenzaldehyde with (3,4-dimethoxyphenyl)acetic acid. 1H NMR data for the title compound and the isomeric (E)-2-acetoxy-3,3′,4′-trimethoxystilbene are reported.
