5421-53-4

Usage

Uses

Used in Antiparasitic Applications:
NSC 8994 is used as an antiparasitic agent for its ability to treat various parasitic infections.
Used in Topical Disinfection:
NSC 8994 is used as a topical disinfectant for its antimicrobial properties, helping to prevent and treat skin infections.
Used in Neurodegenerative Disease Treatment:
NSC 8994 is used as a potential treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's due to its potential neuroprotective effects.
Used in Cancer Therapy:
NSC 8994 is used as a potential anti-cancer agent for its ability to inhibit the growth of certain tumor cells.
Used in Pharmaceutical Research:
NSC 8994 is used in pharmaceutical research to explore its diverse pharmacological properties and potential applications in various therapeutic areas.
However, it is important to note that the use of NSC 8994 is limited due to concerns about its potential neurotoxicity and the development of subacute myelo-optic neuropathy, a severe and potentially irreversible side effect. Further research is needed to fully understand its safety profile and optimize its therapeutic potential.

InChI:InChI=1/C20H26I/c1-19(2,3)15-7-11-17(12-8-15)21-18-13-9-16(10-14-18)20(4,5)6/h7-14H,1-6H3/q-1

Upstream product

• 253185-03-4 tert-butylbenzene 
• 142342-33-4 4,4'-di(tert-butyl)diphenyliodonium tosylate 

Downstream Products

• 68-12-2 N,N-dimethyl-formamide 
• 88888-38-4 C₂₁H₂₈NO 
• 64501-62-8 C₁₈H₂₀NO₂ 
• 107-94-8 chloropropionic acid 
• 253185-03-4 tert-butylbenzene 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 142342-33-4 4,4'-di(tert-butyl)diphenyliodonium tosylate 

Relevant academic research and scientific papers

Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts

Aryliodonium salts have become precursors of choice for the synthesis of18F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with125I?and211At?, initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea=23.5 and 17.1 kcal mol?1with125I?and211At?, respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine.

Bottom Antireflective Coating Compositions

Developable bottom antireflective coating compositions are provided.

BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS

Developable bottom antireflective coating compositions are provided.

PHOTOACTIVE COMPOUNDS

The present application relates to a compound of formula A-X-B, where (i) A-X-B form an ionic compound Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula Q-R500-SO3- or (ii) A-X-B form a non-ionic compound Ac-Xc-Bc, where Ai, Bi, Q, R500, Ac, Bc, and Xc are defined herein. The compounds are useful as photoactive materials.