5421-57-8

Basic information

• Product Name: 2-methyl-N-octylpropanamide
• CAS NO: 5421-57-8
• Molecular Formula: C₁₂H₂₅NO
• Molecular Weight: 199.333
• Mol File: 5421-57-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 275.5°C at 760 mmHg
• Flash Point: 163.5°C
• Density: 0.855g/cm³
• Vapor Pressure: 0.00509mmHg at 25°C
• Refractive Index: 1.438
• CAS DataBase Reference: 2-methyl-N-octylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-octylpropanamide(5421-57-8)
• EPA Substance Registry System: 2-methyl-N-octylpropanamide(5421-57-8)

Safety Data

• Hazardous Substances Data: 5421-57-8(Hazardous Substances Data)

Upstream product

• 111-86-4 n-Octylamine 
• 79-30-1 isobutyryl chloride 

Relevant articles and documents

Utilizing Carbonyl Coordination of Native Amides for Palladium-Catalyzed C(sp3)?H Olefination

PdII-catalyzed C(sp3)?H olefination of weakly coordinating native amides is reported. Three major drawbacks of previous C(sp3)?H olefination protocols, 1) in situ cyclization of products, 2) incompatibility with α-H-containing substrates, and 3) installation of exogenous directing groups, are addressed by harnessing the carbonyl coordination ability of amides to direct C(sp3)?H activation. The method enables direct C(sp3)?H functionalization of a wide range of native amide substrates, including secondary, tertiary, and cyclic amides, for the first time. The utility of this process is demonstrated by diverse transformations of the olefination products.