5421-79-4Relevant academic research and scientific papers
Impurity in tirofiban material, preparation of impurity, and method for detecting impurity in material
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Paragraph 0055; 0058; 0059; 0060; 0061, (2018/09/12)
The invention discloses an impurity in a tirofiban material, preparation of the impurity, and a method for detecting the impurity in the material. The impurity is a compound shown in a formula I, wherein R is selected from the following substituents: hydrogen, halogen, cyano group, amino, nitro, aryl and ceteroary; the R further is hydrogen or pyridyl. The method plays an important practical rolein improvement of the quality of the tirofiban and control of the safety of the tirofiban form the origin.
Nitro-methyl redox coupling: Efficient approach to 2-hetarylbenzothiazoles from 2-halonitroarene, methylhetarene, and elemental sulfur
Nguyen, Thanh Binh,Ermolenko, Ludmila,Al-Mourabit, Ali
supporting information, p. 4218 - 4221 (2013/09/12)
A simple, straightforward, and atom economic approach to 2-hetarylbenzothiazoles starting from 2-halonitroarene, methylhetarene, and elemental sulfur under mild conditions is described. The method is highlighted by the direct redox nitro-methyl reaction for carbon-nitrogen bond formation without an added oxidizing or reducing agent.
ELEMENTAL SULFUR REACTIONS WITH 4-PICOLINE
Gleich Z.,Warnke, Z.,Szafranek, J.,Malinski, E.
, p. 315 - 326 (2007/10/02)
A study of the reaction of the elemental sulfur with 4-picoline is reported.The process was carried out at the boiling point of the 4-picoline under argon.After removing unreacted solids, the reaction products were identified by means of LC, GC, and GC-MS
