5422-73-1

Usage

Uses

Used in Water Treatment:
[hydroxy(pyridin-4-yl)methyl]phosphonic acid is used as a chelating agent for metal ion sequestration in water treatment processes. Its ability to form stable complexes with metal ions helps in removing harmful metal contaminants from water, ensuring cleaner and safer water supplies.
Used in Industrial Processes:
In the industrial sector, [hydroxy(pyridin-4-yl)methyl]phosphonic acid serves as a chelating agent and corrosion inhibitor. Its effectiveness in forming stable complexes with metal ions aids in preventing corrosion and protecting equipment from damage, thus enhancing the efficiency and longevity of industrial processes.
Used in Agriculture:
[hydroxy(pyridin-4-yl)methyl]phosphonic acid is utilized as a chelating agent in agricultural applications, where it helps in the efficient uptake of essential nutrients by plants. By forming stable complexes with metal ions, it promotes better nutrient availability and absorption, leading to improved crop growth and yield.
Used in Pharmaceutical Applications:
HPMPhA has been studied for its potential pharmacological properties, particularly as an anti-inflammatory and anti-tumor agent. Its unique structure and properties make it a promising candidate for the development of new drugs and therapies in the medical field.
Used in Chemical Research:
Due to its versatile nature and unique properties, [hydroxy(pyridin-4-yl)methyl]phosphonic acid is also employed in various chemical research applications. It serves as a valuable compound for studying the interactions between metal ions and organic molecules, as well as for the development of new materials and technologies in the field of chemistry.

Upstream product

• 1156574-40-1 O,O-bis(trimethylsilyl) pyridine-4-yl(trimethylsilyloxy)methylphosphonate 
• 85916-13-8 tert-butyl iminodiacetate 
• 872-85-5 pyridine-4-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of new aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

Simple and versatile synthetic procedures towards new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids via reactions of either aromatic aldehydes or their derivatives with phosphites were elaborated.

Synthesis of new functionalized aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

The convenient syntheses of new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids from the aromatic aldehydes, their derivatives, and phosphorous acid esters in the presence of the effective catalysts (trimethylsilyl trifluoromethanesulfonate, zinc chloride, and cadmium iodide) were developed.

Synthesis of functionalized 1-trimethylsiloxy-substituted O-trimethylsilyl alkylphosphonites and their derivatives

Nucleophilic addition of trimethylsilyl esters of tricoordinate organophosphorus acids to various functionalized aldehydes with vinyl, aryl, and heterocyclic fragments is proposed as a convenient method for the synthesis of new 1-trimethylsiloxysubstituted alkylphosphonites and their derivatives at mild conditions. Also the new functionalized derivatives of these phosphonites, including amino groups as well as certain properties of these compounds as important precursors of new functionalized 1-hydroxyalkylorganophosphorus acids, are presented.

Novel heteroaryl phosphonates as cardioprotective agents

The invention teaches compound of general formula: Wherein: R1 is selected from H and CH3, and R2 is selected from H and OH, or R1 and R2 together form an optionally substituted phenyl ring which is fused to the pyridine ring; and R3 is selected from H, CH3, CH2OH and R4 is selected from H, CH3, CH2OH, R5 is selected from H, phenyl, halogen-substituted phenyl and Wherein R6 and R7 are each independently selected from H, Na+, K+, alkyl and optionally substituted aryl, and X and Y are each independently selected from H, OH and F, or at least one of X and Y is an heteroatom and together with R3 forms a bridge with the proviso that R4 is and N-oxides thereof, and biologically acceptable salts thereof, related compounds, related pharmaceutical compositions, and methods for treating various disorders using such compositions.

Novel hydroxyphosphonate inhibitors of CD-45 tyrosine phosphatase

CD-45 tyrosine phosphatase [E.C. 3.1.3.48] is an important player in the regulation of cell activation and proliferation in hematopoetic cells. As part of a program in immune response modulation, we prepared the first series of small organic molecule inhibitors of CD-45. The preparation and in vitro screening of these hydroxyphosphonates is described herein.

The acidic cleavage of pyridylmethyl(amino)phosphonates. Formation of the corresponding amines

Hydrolysis of 3-pyridylmethyl(amino)phosphonates by means of 20% aq. hydrochloric acid gave corresponding 3-pyridimethyl(amino)phosphonic acids, as expected. However, hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to decomposition of the phosphonates with a cleavage of C-P bond and formation of the corresponding amines. The leaving phosphorus moiety was identified as phosphoric acid. The scope of the reaction is limited to 2- and 4-pyridylmethyl derivatives of aminophosphonic acids and their esters, as well as to the derivatives possessing similar structure. On the contrary, the basic hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to the corresponding monoalkyl esters of the aminophosphonates, and no cleavage of C-P bond was observed in those cases.