54231-35-5

Basic information

• Product Name: 3-Fluoro-2-nitropyridine
• Synonyms: 3-FLUORO-2-NITROPYRIDINE;2-Nitro-3-fluoropyridine;Pyridine, 3-fluoro-2-nitro- (9CI);3-FLUORO-2-NITROPYRIDINE,98%;3-Fluoro-2-nitropyridine (2-Nitro-3-Fluoropyridine);Pyridine,3-fluoro-2-nitro-;3-Fluoro-2-nitropyridine≥ 97% (HPLC)
• CAS NO: 54231-35-5
• Molecular Formula: C₅H₃FN₂O₂
• Molecular Weight: 142.09
• Product Categories: NITRO;Miscellaneous;Pyridine series;Halides;Pyridines;Pyridine;CHIRAL CHEMICALS;Fluorine series;alkyl Fluorine| nitro-compound
• Mol File: 54231-35-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 35°C
• Boiling Point: 255.809 °C at 760 mmHg
• Flash Point: 108.51 °C
• Appearance: light brown crystal powder or liquid
• Density: 1.439 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.01±0.22(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Fluoro-2-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-2-nitropyridine(54231-35-5)
• EPA Substance Registry System: 3-Fluoro-2-nitropyridine(54231-35-5)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 36/37/39-45-24/25
• RIDADR: UN3261
• TSCA: N
• HazardClass: IRRITANT
• Hazardous Substances Data: 54231-35-5(Hazardous Substances Data)

Usage

Chemical Properties

light brown crystal powder or liquid

Uses

A specialty product for proteomics research applications.

Upstream product

• 13269-19-7 3-amino-2-nitropyridine 

Downstream Products

• 123348-60-7 3-(2-benzoylhydrazino)-2-nitropyridine 
• 165615-64-5 (S)-2-methyl-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one 
• 165615-64-5 (R)-2-methyl-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one 
• 128102-80-7 2-methylpyrido<2,3-b>pyrazin-3(4H)-one 
• 1873373-33-1 (S)-6-amino-5-[(4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl)oxy]-N-methylpyridine-3-carboxamide 
• 1873373-33-1 (R)-6-amino-5-[(4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl)oxy]-N-methylpyridine-3-carboxamide 
• 1016-93-9 2-Phenyl-1H-imidazo<4,5-b>pyridine 
• 1613148-62-1 3-(1-(2,6-dichlorophenyl)ethoxy)-2-nitropyridine 

Relevant articles and documents

Cross-coupling reaction of 2-halo1-methyl-1H-imidazo[4,5-b]pyridine offers a new synthetic route to mutagenic heterocyclic amine-PHIP and DMIP

A modified synthetic approach to the synthesis of heterocyclic food mutagens, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and 2-amino-1,6-dimethylimidazo[4,5-b]pyridine (DMIP) is reported. This route highlights an optimized palladium catalysed Buchwald cross-coupling of 2-halo-1-methyl-imidazo[4,5-b]pyridine with benzophenoneimine followed by acidic hydrolysis to yield compound 7. Using finely tailored conditions, Suzuki cross-coupling reactions with highly efficient catalytic systems were performed as the final step on 8 to introduce the aryl group and methyl group on the heterocyclic core.

Synthesis and Spectral Data of Pyrido-as-triazines

The pyrido-as-triazine and its 3-phenyl derivatives were prepared via cyclisation with polyphosphoric acid of suitable 3-substituted 2-aminopyridines obtained by reduction of the corresponding 2-nitropyridines.The 3-substituted 2-nitropyridines wer