54236-98-5 Usage
Uses
Used in Pharmaceutical Industry:
2,4-Diamino-5-methoxymethylpyrimidine serves as a key intermediate in the synthesis of pharmaceuticals, specifically for the development of antiviral drugs. Its unique structure allows for the creation of compounds that can effectively target and combat viral infections.
Used in the Synthesis of Biologically Active Compounds:
In the field of biochemistry, 2,4-Diamino-5-methoxymethylpyrimidine is utilized in the production of nucleosides and nucleotides, which are essential for various biological processes, including DNA and RNA synthesis.
Used in Antiviral Research:
2,4-Diamino-5-methoxymethylpyrimidine is employed as a building block in the design and synthesis of new antiviral agents. Its structural properties make it a promising candidate for the development of drugs that can inhibit viral replication and reduce the severity of viral diseases.
Used in Anticancer Research:
2,4-Diamino-5-methoxymethylpyrimidine also holds potential in anticancer research, where it can be used to develop novel therapeutic agents that target cancer cells. Its ability to be modified and incorporated into various chemical structures makes it a valuable asset in the creation of anticancer drugs.
Overall, 2,4-Diamino-5-methoxymethylpyrimidine is a multifaceted chemical compound with applications spanning across the pharmaceutical, biochemical, and medical research industries, particularly in the areas of antiviral and anticancer drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 54236-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,2,3 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 54236-98:
(7*5)+(6*4)+(5*2)+(4*3)+(3*6)+(2*9)+(1*8)=125
125 % 10 = 5
So 54236-98-5 is a valid CAS Registry Number.
54236-98-5Relevant academic research and scientific papers
Syntheses of Antibacterial 2,4-Diamino-5-benzylpyrimidines. Ormetoprim and Trimethoprim
Manchand, Percy S.,Rosen, Perry,Belica, Peter S.,Oliva, Gloria V.,Perrotta, Agostino V.,Wong, Harry S.
, p. 3531 - 3535 (2007/10/02)
A general and mild method for the synthesis of 2,4-diamino-5-benzylpyrimidines was achieved by the Friedel-Crafts reaction between 2-(methoxymethylene)-3-methoxypropanenitrile (10) and an activated aromatic substrate followed by treatment with guanidine.The method is illustrated by a synthesis of ormetoprim (2) in 75percent overall yield from 3,4-dimethoxytoluene (12).Efficient syntheses of trimethoprim (1) and 2 were also accomplished via prior base-catalyzed 1,3-prototropic isomerization of cinnamonitriles 19 and 20, respectively, followed by condensation with guanidine. 12 was prepared from 3-bromo-4-methoxytoluene by a Cu(I)-catalyzed displacement of bromine by methoxide and 4,5-dimethoxy-2-methylbenzaldehyde was obtained from 12 in 87percent yield by a pyridine-catalyzed Vilsmeier reaction using DMF-POCl3.
Process for substituted 5-benzyl-2,4-diamino-pyrimidines
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, (2008/06/13)
A process for preparing a compound of the formula STR1 wherein R1 and R2 are lower alkoxy or taken together are METHYLENEDIOXY; R3 is lower alkyl or hydrogen, which comprises the step of reacting an aromatic compound of the formula STR2 wherein R1, R2 and R3 are as previously described, with a diamino-pyrimidine of the formula STR3 wherein R4 is lower alkoxy, benzyloxy, hydroxy or halogen, in the presence of an inorganic or organic acid selected from the group consisting of ortho-phosphoric acid, poly-phosphoric acid, hydrohalic acids and tri-haloacetic acids, at a temperature in the range of from about 50° C. to about 110° C., is described.
