5424-08-8

Basic information

• Product Name: 2,2-diphenyl-4-(piperidin-1-yl)butanenitrile
• CAS NO: 5424-08-8
• Molecular Formula: C₂₁H₂₄N₂
• Molecular Weight: 304.4287
• Mol File: 5424-08-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 469.2°C at 760 mmHg
• Flash Point: 199.9°C
• Density: 1.063g/cm³
• Vapor Pressure: 5.63E-09mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2,2-diphenyl-4-(piperidin-1-yl)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diphenyl-4-(piperidin-1-yl)butanenitrile(5424-08-8)
• EPA Substance Registry System: 2,2-diphenyl-4-(piperidin-1-yl)butanenitrile(5424-08-8)

Safety Data

• Hazardous Substances Data: 5424-08-8(Hazardous Substances Data)

Usage

General Description

2,2-diphenyl-4-(piperidin-1-yl)butanenitrile is a chemical compound with the molecular formula C24H26N2. It is a nitrile derivative that contains a piperidine ring and two phenyl groups. 2,2-diphenyl-4-(piperidin-1-yl)butanenitrile has potential applications in medicinal chemistry and drug development, particularly as a building block for the synthesis of various pharmaceuticals and biologically active molecules. It may also have use as a ligand in coordination chemistry and in organic synthesis. The compound's properties and reactivity make it a valuable tool for chemical research and development.

Upstream product

• 110-89-4 piperidine 
• 39186-58-8 4-bromo-2,2-diphenylbutyronitrile 
• 86-29-3 Diphenylacetonitrile 

Downstream Products

• 561-48-8 norpipanone 
• 111979-87-4 1-(3-cyano-3,3-diphenyl-propyl)-1-methyl-piperidinium; bromide 
• 102762-52-7 2,2-diphenyl-4-piperidino-butyric acid ethyl ester 
• 66859-76-5 4,4-diphenyl-6-piperidino-hexan-3-one-imine 
• 115322-03-7 3,3-diphenyl-1-piperidino-heptan-4-one 
• 103033-15-4 1,2,2-triphenyl-4-piperidino-butan-1-one 
• 3540-95-2 fenpiprane 
• 59289-78-0 2,2-diphenyl-4-(1-piperidyl)butan-1-amine 
• 77-01-0 Fenpipramide 
• 102597-35-3 2,2-diphenyl-4-piperidino-butyric acid 
• 66827-65-4 4,4-diphenyl-6-piperidino-hexan-3-on-acetylimine; hydrochloride 
• 59882-12-1 1-[3-(5-methyl-[1,3,4]oxadiazol-2-yl)-3,3-diphenyl-propyl]-piperidine 

Relevant articles and documents

Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents

Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to previously identified CRAs, and found promising novel compounds. These compounds show encouraging results in a coumarin labeled chloroquine uptake assay, exhibiting a dose response in resensitising parasites to the antimalarial effects of chloroquine. Selected compounds show consistent potency across a panel of chloroquine and artemisinin sensitive and resistant parasites, and a wide therapeutic window. This data supports further study of CRAs in the treatment of malaria and, ultimately, their use in chloroquine-based combination therapies.