5424-08-8 Usage
Uses
Used in Medicinal Chemistry:
2,2-diphenyl-4-(piperidin-1-yl)butanenitrile is used as a building block for the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Drug Development:
2,2-diphenyl-4-(piperidin-1-yl)butanenitrile is utilized in drug development as a key intermediate in the synthesis of complex molecules with potential medicinal properties. Its presence in the molecular structure can influence the pharmacological activity and efficacy of the final drug product.
Used in Coordination Chemistry:
2,2-diphenyl-4-(piperidin-1-yl)butanenitrile is used as a ligand in coordination chemistry, where it can form stable complexes with metal ions. This application is valuable for the study of metal-ligand interactions and the development of new materials with specific properties.
Used in Organic Synthesis:
2,2-diphenyl-4-(piperidin-1-yl)butanenitrile is employed in organic synthesis as a valuable tool for the preparation of a wide range of organic molecules. Its reactivity and functional groups make it a useful component in the synthesis of complex organic compounds for research and development purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 5424-08-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,2 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5424-08:
(6*5)+(5*4)+(4*2)+(3*4)+(2*0)+(1*8)=78
78 % 10 = 8
So 5424-08-8 is a valid CAS Registry Number.
5424-08-8Relevant academic research and scientific papers
Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents
Boudhar, Aicha,Ng, Xiao Wei,Loh, Chiew Yee,Chia, Wan Ni,Tan, Zhi Ming,Nosten, Francois,Dymock, Brian W.,Tan, Kevin S.W.
, p. 231 - 249 (2016/05/24)
Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to previously identified CRAs, and found promising novel compounds. These compounds show encouraging results in a coumarin labeled chloroquine uptake assay, exhibiting a dose response in resensitising parasites to the antimalarial effects of chloroquine. Selected compounds show consistent potency across a panel of chloroquine and artemisinin sensitive and resistant parasites, and a wide therapeutic window. This data supports further study of CRAs in the treatment of malaria and, ultimately, their use in chloroquine-based combination therapies.
Process for the preparation of tertiary amines
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, (2008/06/13)
Certain tertiary amines useful as pharmaceuticals are prepared in improved yields by condensing a cyclic secondary amine with a primary alkyl halide in an aqueous medium in the presence of an acid acceptor.
