54252-56-1

Usage

Uses

Used in Pharmaceutical Industry:
C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE is used as a potential pharmaceutical agent for its unique chemical structure, which may exhibit various pharmacological properties. The benzooxazine ring and the methylamine group present in the compound can be utilized for drug design and development, targeting specific biological activities and therapeutic effects.
Used in Biochemical Research:
In the field of biochemistry, C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE serves as a valuable compound for studying its interactions with biological systems and understanding its potential effects on cellular processes. Further research may reveal its role in modulating specific signaling pathways or its ability to target certain diseases at the molecular level.

InChI:InChI=1/C9H12N2O/c10-5-7-6-12-9-4-2-1-3-8(9)11-7/h1-4,7,11H,5-6,10H2

Upstream product

• 54252-58-3 N-(3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-succinimide 
• 54252-57-2 2-(3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl)isoindole-1,3-dione 
• 54252-53-8 2-[3-(2-nitrophenoxy)-2-oxypropyl]isoindole-1,3-dione 
• 54252-49-2 2-[2-hydroxy-3-(2-nitrophenoxy)propyl]isoindole-1,3-dione 
• 54252-54-9 N-[3-(2-nitro-phenoxy)-2-oxo-propyl]-succinimide 
• 21407-49-8 2-nitrophenyl glycidyl ether 

Downstream Products

• 57682-18-5 (3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-(3,4,5-trimethoxy-benzyl)-amine 
• 57682-15-2 benzyl-(3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-amine 
• 167024-13-7 benzyl 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-3-carboxylate 
• 167024-12-6 benzyl 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-1-one-3-carboxylate 
• 167024-11-5 benzyl [4-(2-chloroacetyl)-3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl]carbamate 
• 167024-14-8 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine 
• 85834-25-9 2-{2-[4-(4-Chloro-phenyl)-piperazin-1-yl]-ethyl}-2,3,3a,4-tetrahydro-5-oxa-2,9b-diaza-cyclopenta[a]naphthalen-1-one 
• 57682-21-0 3-benzyl-3,4,4a,5-tetrahydro-benzo[b]pyrazino[1,2-d][1,4]oxazine-1,2-dione 
• 57682-25-4 1-(4-fluoro-phenyl)-4-(1,2,4a,5-tetrahydro-4H-benzo[b]pyrazino[1,2-d][1,4]oxazin-3-yl)-butan-1-one 
• 167024-10-4 benzyl (3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl)carbamate 

Relevant academic research and scientific papers

New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes

A new series of compounds were designed as structural analogues of the α1-AR ligand RN5 (4), characterized by a tricyclic 5H-pyrimido[5,4-b]indole-(1H,3H)2,4-dione system connected through an alkyl chain to a phenylpiperazine (PP) moiety. These compounds were synthesized and tested in binding assays on human α1A-AR, α1B-AR, and α1D-AR subtypes expressed in HEK293 cells. Several structural modifications were performed on the PP moiety, the tricyclic system, and the connecting alkyl chain. Many of the new molecules showed a preferential affinity for the α1D-AR subtype. Some compounds, including 39 and 40, displayed substantial α1D-AR selectivity with respect to α1A-AR, α1B-AR, serotonergic 5-HT1A, 5-HT1B, 5-HT2A, and dopaminergic D1 and D2 receptors. Two conformationally rigid analogues of 4, useful for studying the architecture of the receptor/ligand complex, were also prepared and tested. A subset of the new compounds was then used to evolve a preliminary pharmacophore model for α1D-AR antagonists, based on a more generalized model we had developed for α1-AR antagonists. This new model rationalized the relationships between structural properties and biological data of the pyrimido[5,4-b]indole compounds, as well as other compounds.

Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT(1A) receptor

Hindered rotation analogs of the antipsychotic mazapertine (1) were prepared. These compounds exhibited high affinity for the 5-HT(1A) receptor, but not for other serotonin or dopamine receptors. The related β-carboline structures were also synthesized an

Imidazo[5,1-c][1,4]benzoxazin-1-one

Cyclic derivatives of 1,4-benzoxazine and 1,4-benzothiazine are disclosd, such as, for instance, 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-imidazo[5,1-c][1,4]benzoxazin-1-one and 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-8-chloro-imidazo[5,1-c][1,4]benzoxaz