54252-56-1

Basic information

• Product Name: C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE
• Synonyms: C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE;(3,4-Dihydro-2hH-benzo[1,4]oxazin-3-yl)methylamine;(3,4-Dihydro-2H-benzo[b][1,4]oxazin-3-yl)MethanaMine;(3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)MethanaMine hydrochloride;3-(Aminomethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine;NSC 173322;3,4-Dihydro-2H-1,4-benzoxazine-3-methanamine;3,4-dihydro-2H-1,4-benzoxazin-3-ylmethanamine
• CAS NO: 54252-56-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Mol File: 54252-56-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 312.2 °C at 760 mmHg
• Flash Point: 142.6 °C
• Appearance: /
• Density: 1.108 g/cm³
• Vapor Pressure: 0.000538mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE(54252-56-1)
• EPA Substance Registry System: C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE(54252-56-1)

Safety Data

• Hazardous Substances Data: 54252-56-1(Hazardous Substances Data)

Usage

General Description

C-(3,4-Dihydro-2H-benzo[1,4]oxazin-3-yl)-methylamine is a chemical compound with a complex molecular structure. It is an organic compound containing a benzooxazine ring and a methylamine group. C-(3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-3-YL)-METHYLAMINE has potential pharmaceutical applications due to its unique chemical structure, which may have biological activity. The presence of the benzooxazine ring suggests that it may have various pharmacological properties, and the methylamine group can be a valuable moiety for drug design. Further research and studies may be conducted to explore the potential uses and effects of C-(3,4-Dihydro-2H-benzo[1,4]oxazin-3-yl)-methylamine in the fields of medicine and biochemistry.

InChI:InChI=1/C9H12N2O/c10-5-7-6-12-9-4-2-1-3-8(9)11-7/h1-4,7,11H,5-6,10H2

Upstream product

• 54252-58-3 N-(3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-succinimide 
• 54252-57-2 2-(3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl)isoindole-1,3-dione 
• 54252-54-9 N-[3-(2-nitro-phenoxy)-2-oxo-propyl]-succinimide 
• 21407-49-8 2-nitrophenyl glycidyl ether 
• 54252-49-2 2-[2-hydroxy-3-(2-nitrophenoxy)propyl]isoindole-1,3-dione 
• 54252-53-8 2-[3-(2-nitrophenoxy)-2-oxypropyl]isoindole-1,3-dione 

Downstream Products

• 57682-21-0 3-benzyl-3,4,4a,5-tetrahydro-benzo[b]pyrazino[1,2-d][1,4]oxazine-1,2-dione 
• 57682-25-4 1-(4-fluoro-phenyl)-4-(1,2,4a,5-tetrahydro-4H-benzo[b]pyrazino[1,2-d][1,4]oxazin-3-yl)-butan-1-one 
• 85834-25-9 2-{2-[4-(4-Chloro-phenyl)-piperazin-1-yl]-ethyl}-2,3,3a,4-tetrahydro-5-oxa-2,9b-diaza-cyclopenta[a]naphthalen-1-one 
• 167024-14-8 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine 
• 167024-11-5 benzyl [4-(2-chloroacetyl)-3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl]carbamate 
• 167024-12-6 benzyl 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-1-one-3-carboxylate 
• 167024-13-7 benzyl 1,2,3,4,4a,5-hexahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-3-carboxylate 
• 167024-10-4 benzyl (3,4-dihydro-2H-benzo[1,4]oxazin-1-ylmethyl)carbamate 
• 57682-15-2 benzyl-(3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-amine 
• 57682-18-5 (3,4-dihydro-2H-benzo[1,4]oxazin-3-ylmethyl)-(3,4,5-trimethoxy-benzyl)-amine 

Relevant articles and documents

New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes

A new series of compounds were designed as structural analogues of the α1-AR ligand RN5 (4), characterized by a tricyclic 5H-pyrimido[5,4-b]indole-(1H,3H)2,4-dione system connected through an alkyl chain to a phenylpiperazine (PP) moiety. These compounds were synthesized and tested in binding assays on human α1A-AR, α1B-AR, and α1D-AR subtypes expressed in HEK293 cells. Several structural modifications were performed on the PP moiety, the tricyclic system, and the connecting alkyl chain. Many of the new molecules showed a preferential affinity for the α1D-AR subtype. Some compounds, including 39 and 40, displayed substantial α1D-AR selectivity with respect to α1A-AR, α1B-AR, serotonergic 5-HT1A, 5-HT1B, 5-HT2A, and dopaminergic D1 and D2 receptors. Two conformationally rigid analogues of 4, useful for studying the architecture of the receptor/ligand complex, were also prepared and tested. A subset of the new compounds was then used to evolve a preliminary pharmacophore model for α1D-AR antagonists, based on a more generalized model we had developed for α1-AR antagonists. This new model rationalized the relationships between structural properties and biological data of the pyrimido[5,4-b]indole compounds, as well as other compounds.

Imidazo[5,1-c][1,4]benzoxazin-1-one

Cyclic derivatives of 1,4-benzoxazine and 1,4-benzothiazine are disclosd, such as, for instance, 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-imidazo[5,1-c][1,4]benzoxazin-1-one and 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-8-chloro-imidazo[5,1-c][1,4]benzoxaz