54256-41-6

Usage

Uses

Used in Pharmaceutical Development:
BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its potential role in inhibiting dihydroorotate dehydrogenase. This enzyme inhibition can be leveraged to develop treatments targeting diseases where pyrimidine nucleotide biosynthesis is a critical factor.
Used in Agrochemical Synthesis:
In the agrochemical industry, BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID is utilized as a building block in the creation of compounds that can be used in pest and disease control, potentially enhancing crop yields and quality through targeted biological activity.
Used in Medicinal Chemistry Research:
BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID serves as a subject of study in medicinal chemistry, where its properties and interactions with biological systems are being explored. This research is crucial for identifying its potential therapeutic applications and optimizing its use in treating various diseases.
Further research is essential to fully understand the capabilities and limitations of BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID, ensuring its safe and effective incorporation into new compounds and therapies.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 49607-01-4 (R)-2-amino-2-cyclopropylacetic acid 
• 1259387-41-1 C₁₆H₂₇NO₄ 
• 1259387-42-2 C₁₁H₁₉NO₂ 
• 688318-00-5 carbonic acid 3-cyclopropylallyl ester methyl ester 
• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 4248-19-5 tert-butyl carbazate 
• 15785-26-9 (S)-2-amino-2-cyclopropyl acetic acid 

Downstream Products

• 63009-44-9 (6R)-3-benzyl-7t-((R)-2-tert-butoxycarbonylamino-2-cyclopropyl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 138326-69-9 (R)-methyl 2-amino-2-cyclopropylacetate hydrochloride 
• 1354692-87-7 (R)-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-cyclopropyl-acetic acid 
• 1354692-86-6 (R)-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-cyclopropyl-acetic acid methyl ester 
• 1394017-93-6 tert-butyl 2-(4-chlorophenyl)-1-cyclopropyl-2-oxoethylcarbamate 
• 1394017-94-7 2-amino-1-(4-chlorophenyl)-2-cyclopropylethanone 
• 1394017-66-3 N-(2-(4-chlorophenyl)-1-cyclopropyl-2-oxoethyl)benzamide 
• 1590397-84-4 tert-butyl 1-cyclopropyl-2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethylcarbamate 
• 1590397-06-0 2-cyclopropyl-2-(4-fluorobenzenesulfonylamino)-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)acetamide 
• 1001414-89-6 tert-butyl (R)-(1-cyclopropyl-2-hydroxyethyl)carbamate 
• 1334675-84-1 2-(4-trifluoromethylphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide 

Relevant academic research and scientific papers

Synthesis of cyclopropane-containing building blocks via Ir-catalyzed enantioselective allylic substitution reaction

Chiral cyclopropane-containing building blocks, which are very important synthetic intermediates for natural products or pharmaceuticals, were easily synthesized via Ir-catalyzed enantioselective allylic substitution reaction.

Ir-Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates

The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62–82 % yield and 87–98 % ee. The products generated through this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.

Substituted Pyrrolidine Amides II

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

CERTAIN 1-(D-CYCLOPROPYLGLYCINYL)-4-(PIPERIDIN-4-YL)PIPERAZINE COMPOUNDS AS INHIBITORS OF THE SERINE PROTEASE FACTOR XA

The compounds of formula (I) in which R represents a hydrogen atom or a fluorine atom, or a pharmaceutically acceptable salt thereof are Factor Xa inhibitors useful in the treatment of thrombotic disorders.