54258-41-2Relevant articles and documents
Self-assembly of novel molecular complexes of 1,10-phenanthroline and 5-amino-1,10-phenanthroline and evaluation of their in vitro antitumour activity
Kaloyanov, Nikolay,Alexandrova, Radostina,Wesselinova, Diana W.,Mayer-Figge, Heike,Sheldrick, William S.,Dimitrov, Georgi D.
, p. 1992 - 1996 (2011)
Novel molecular complexes of 1,10-phenanthroline (phen) and 5-amino-1,10-phenanthroline (5-NH2-phen) [(5-NH2-phen) 2(phen) (H2O)3 (1), (phen) 2(imidazole) (H+) (BF4-) (2), (phen)2(benzimidazole) (H+) (BF4-) (3), (5-NH2-phen)4(H2O)3 (4), and (phen)3 (indole) (H+) (BF4-) (5)] were synthesized via self-assembly processes and their in vitro anticancer activity was investigated. The structures of the compounds were confirmed by UV, FTIR, CIMS(CH4) and elemental analysis. The crystal structure of 2 was determined by X-ray diffraction. Cytotoxicity of the substances was measured using the cultivated human tumour cell lines HepG2, HEp-2, and 8-MB-GA. The tested substances showed different activity depending on the cell line and amount used. Substances 2 and 3 were not toxic to the non-tumour cells (Lep-3), but significantly toxic to all tumour ones. This is not the case with compounds 4 and 5, which are non-toxic towards carcinogenic cell lines, but even stimulate both HepG2 and HEp-2.
Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion
Lee, Soo Jin,Lee, Shim Sung,Lah, Myoung Soo,Hong, Jae-Min,Jung, Jong Hwa
, p. 4539 - 4541 (2006)
Functionalized silica nanotube (FSNT) possessing the phenanthroline moiety as a fluorescent receptor was fabricated by sol-gel reaction, and the binding ability of FSNT with metal ions was evaluated by fluorophotometry. The Royal Society of Chemistry 2006.
Interaction of sulfonated ruthenium(ii) polypyridine complexes with surfactants probed by luminescence spectroscopy
Garcia-Fresnadillo, David,Orellana, Guillermo
, p. 2708 - 2730 (2001)
Novel anionic [RuL2L′]2- complexes, where L stands for (1,10-phenanthroline-4,7-diyl)bis(benzenesulfonate) (pbbs; 3a) or (2,2′-bipyridine)-4,4′-disulfonate (bpds; 3b), and L′ is N-(1,10-phenanthrolin-5-yl)tetradecanamide (pta; 2a) or N-(1,10-phenanthrolin-5-yl)acetamide (paa; 2b), were synthesized, and their interaction with the prototypical surfactants sodium dodecylsulfate (SDS), cetyl trimethyl ammonium bromide (CTAB), and Triton X-100 (TX-100) was investigated by electronic absorption, luminescence spectroscopy, emission-lifetime determinations, and O2-quenching measurements. [Ru(bpds)2(pta)]2- (5a) displayed cooperative self-aggregation in aqueous medium at concentrations above 1.3 μM; the observed association was enhanced in the presence of either β-cyclodextrin or NaCl. This amphiphilic Ru11 compound showed the strongest interaction with all the detergents tested: nucleation of surfactant molecules around the luminescent probe was observed below their respective critical micellar concentrations. As much as a 12-fold increase of the emission intensity and a 3-fold rise in the lifetime were measured for 5a bound to TX-100 micelles; the other complexes showed smaller variations. The O2-quenching rate constants decreased up to 1/8 of their original value in H2O (e.g., for [Ru(bpds)2(pta)]2- (6a) bound to CTAB micelles). Luminescence-lifetime experiments in H2O/D2O allowed the determination of the metal-complex fraction exposed to solvent after binding to surfactant micelles. For instance, such exposure was as low as 25% for pta complexes · CTAB aggregates. The different behaviors observed were rationalized in terms of the Ru11 complex structure, the electrostatic/hydrophobic interactions, and the probe environment.
N-Phenanthroline glycosylamines: Synthesis and copper(II) complexes
Duskova, Katerina,Gude, Lourdes,Arias-Pérez, María-Selma
, p. 1071 - 1076 (2014)
A series of novel N-(1,10-phenanthrolin-5-yl)-β-glycopyranosylamines was obtained with excellent stereoselectivity and synthetically useful yields by treatment of 5-amino-1,10-phenanthroline with different unprotected monosaccharides, using (NH4)2SO4 as an efficient promoter. Copper(II) complexes having a 2:1 mole ratio of the bidentate ligand phenanthroline N-glycoside and the metal were also prepared.
Metal coordination as a tool for controlling the self-assembling and gelation properties of novel type cholic amide-phenanthroline gelating agent
Dukh,?aman,Kroulík,?erny,Pouzar,Král,Dra?ar
, p. 4069 - 4076 (2003)
(3α,7α,12α)-Trihydroxy-N-[1,10-phenanthrolin-5-yl]- 5β-cholan-24-amide was found to be a powerful gelating agent for methanol-water in gelator to solvent ratio starting from 0.1% in absence of metal ion. Formation of phenanthroline-zinc (II) 2:1 complex changes dramatically gelating properties; when stored, it dissolves into clear solution without Tyndall effect and this solution, when heated to ca. 70°C reversibly forms a gel again, without chemical change as proven by NMR spectrometry. Structures of the gels of cholic amide-phenanthroline and its Zn2+ complex were studied by SEM.
pH responsive Eu(III)-phenanthroline supramolecular conjugate: Novel off-on-off luminescent signaling in the physiological pH range
Gunnlaugsson, Thorfinnur,Leonard, Joseph P.,Senechal, Katell,Harte, Andrew J.
, p. 12062 - 12063 (2003)
The formation of luminescent supramolecular ternary complexes in water: delayed luminescence sensing of aromatic carboxylates using coordinated unsaturated cationic heptadenatate lanthanide ion complexes. Copyright
A shining proposal for the detection of dissolved O2 in aqueous medium: Self-calibrated optical sensing via a covalent hybrid structure of carbon-dots&Ru
Jiang, Yuanyuan,Liu, Liang,Liu, Xuelian,Mao, Li,Wang, Hongjun,Zhao, Yanping
, (2021/06/16)
O2 is a life-supporting gas and has been widely recognized as an important analyte in life science, medical care and environmental science. Optical sensing for gaseous oxygen has been widely reported owing to the simple, cost-effective and easy-to-go procedure. On the other hand, optical sensors for dissolved oxygen in aqueous media have been rarely reported, since most of them are incompatible with water, leading to poor sensitivity and linearity. In this effort, we tried the combination of Ru(II)-bpy complex and carbon dots (CDs) via covalent bonds, where bpy = bipyridine. A hybrid structure, named as Ru@CD, was constructed for the detection of dissolved oxygen, using Ru(II)-bpy as sensing probe and CDs as water-compatible supporting matrix. Ru@CD was carefully characterized to confirm its hybrid structure. Detailed analysis suggested that its emission showed self-calibrated sensing signals for dissolved oxygen. A good linearity of 99.1% was realized. Its sensitivity (3.18) was higher than most literature values for dissolved oxygen detection. Its working equation was confirmed as a corrected Stern-Volmer equation (Lehrer mode). Good selectivity and signal stability were observed.
Molecular engineering for optical properties of 5-substituted-1,10-phenanthroline-based Ru(ii) complexes
Beley, Marc,Blanchard-Desce, Mireille,Chevreux, Sylviane,Gros, Philippe C.,Lawson-Daku, Latévi Max,Lemercier, Gilles,Mongin, Olivier,Moreau, Juliette,Rousset, Elodie
, p. 10119 - 10132 (2021/08/03)
A series of homo- and heteroleptic Ru(ii) complexes[Ru(phen)3?n(phen-X)n](PF6)2(n= 0-3, X = CN, epoxy, H, NH2) were prepared and characterized. The influence of electron-withdrawing or electron-releasing substituents of the 1,10-phenanthroline ligands on the photo-physical properties was evaluated. It reveals fundamental interests in the fine tuning of redox potentials and photo-physical characteristics, depending both on the nature of the substitution of the ligand, and on the symmetry of the related homo- or heteroleptic complex. These complexes exhibit linear absorption and two-photon absorption (2PA) cross-sections over a broad range of wavelength (700-900 nm) due to absorption in the intra-ligand charge transfer (ILCT) and the metal-to-ligand charge transfer (MLCT) bands. These 2PA properties were more particularly investigated in the 700-1000 spectral range for a family of complexes bearing electro-donating ligands (phen-NH2).
