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5426-09-5

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5426-09-5 Usage

General Description

4,10-DIOXATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE is a chemical compound with a complex and unique ring structure. It contains a tricyclic ring system with two oxygen atoms and a double bond, as well as a ketone functional group. 4,10-DIOXATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE has potential applications in organic synthesis and medicinal chemistry due to its interesting structure and reactivity. Its properties and potential uses make it an interesting target for further research and exploration in the field of organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 5426-09-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,2 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5426-09:
(6*5)+(5*4)+(4*2)+(3*6)+(2*0)+(1*9)=85
85 % 10 = 5
So 5426-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h1-6H

5426-09-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3a,4,7,7a-Tetrahydro-4,7-epoxyisobenzofuran-1,3-dione

1.2 Other means of identification

Product number -
Other names 4,10-DIOXATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5426-09-5 SDS

5426-09-5Relevant articles and documents

Organoseleno cytostatic derivatives: Autophagic cell death with AMPK and JNK activation

Garnica, Pablo,Encío, Ignacio,Plano, Daniel,Palop, Juan A.,Sanmartín, Carmen

, p. 234 - 246 (2019)

Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds were screened for their potency and selectivity against seven tumor cell lines and two non-malignant cell lines. Results showed that MCF-7 cells were especially sensitive to the treatment, with seven compounds presenting GI50 values below 10 μM. Notably, the carboxylic selenocyanate 8b and the cyclic imide 10a also displayed high selectivity for tumor cells. Treatment of MCF-7 cells with these compounds resulted in cell cycle arrest at S phase, increased levels of pJNK and pAMPK and caspase independent cell death. Autophagy inhibitors wortmannin and chloroquine partially prevented 8b and 10a induced cell death. Consistent with autophagy, increased Beclin1 and LC3-IIB and reduced SQSTM1/p62 levels were detected. Our results point to 8b and 10a as autophagic cell death inducers.

Synthesis, crystal structure, spectroscopic properties and potential anti-cancerous activities of four unsaturated bis-norcantharimides

Cheng, Shuang-Shuang,Shi, Yan,Ma, Xiao-Na,Xing, Dian-Xiang,Liu, Lian-Dong,Liu, Yun,Zhao, Yun-Xue,Sui, Qi-Cheng,Tan, Xue-Jie

, p. 228 - 240 (2016)

Four unsaturated norcantharimide (UNCI) dimers were synthesized and characterized by elemental analysis, ESI-QTOF-MS, FT/IR, UV-Vis, 1H and 13C NMR as well as single crystal X-ray diffraction. In addition, theoretical studies have been investigated to compare with the experimental findings. Introduction of various lengths of single bond link chains provides high conformational flexibility and thus unusual molecular and crystal structures for dimers. Two of the four dimers twist into helicate, but crystallize into centrosymmetric lattice; one adopts approximately centrosymmetric conformer, but packs into non-centrosymmetric polar space group (P21). Moreover, in vitro cytotoxic activities of four UNCI dimers and their corresponding saturated NCI dimers were evaluated. All four UNCI dimers are inactive and one NCI dimer shows modest cytotoxicity. These findings were compared with the relevant results in literature. It is found that the antitumor properties of UNCI/NCI dimers depend mainly on the length of link chains (the longer chain, the higher therapeutic efficacy) and have relationship with the double bond, which requires more experimental support.

ACCELERATION OF A DIELS-ALDER REACTION IN AN ULTRACENTRIFUGE

Dolata, Daniel P.,Bergman, Rolf

, p. 707 - 708 (1987)

The reaction rate for the Diels-Alder reaction between maleic anhydride and furan is increased when performed in an ultracentrifuge.

Albumin-micelles via a one-pot technology platform for the delivery of drugs

Jiang, Yanyan,Liang, Mingtao,Svejkar, Domenic,Hart-Smith, Gene,Lu, Hongxu,Scarano, Wei,Stenzel, Martina H.

, p. 6394 - 6397 (2014)

A new micelle delivery platform based on albumin coated nanoparticles is able to selectively deliver the payload to cancerous cells while healthy cells remain less affected. The technology is simple and can be used in a one-pot procedure. the Partner Organisations 2014.

Bridging from the Sequence to Architecture: Graft Copolymers Engineering via Successive Latent Monomer and Grafting-from Strategies?

Zhang, Yajie,Cao, Xiaohuan,Gao, Yang,Xie, Yujie,Huang, Zhihao,Zhang, Zhengbiao,Zhu, Xiulin

supporting information, p. 1273 - 1280 (2021/05/04)

The on-demand building copolymer structures, from sequence to architecture, is crucial in understanding the relation between polymer structure and property, meanwhile motivating the innovation of polymer hierarchy. However, the challenge is conspicuous for complicated polymer structures from inherently intricate polymerization. In this work, copolymers with tailored grafting density and distributions were achieved using successive latent monomer and grafting-from strategies. The hydroxyl group functionalized furan/maleimide adduct (FMOH) was selected as the latent monomer for RAFT polymerization of an array of copolymers with tailored localization of hydroxyl group along the main chain. The hydroxyl group further initiated the ring opening polymerization (ROP) of L-lactide or ε-caprolactone, resulting in a library of multicomponent copolymers via grafting-from strategy. The initiating efficiency reached to ~100% with variable molecular weight (21300—58600 Da) and narrow distributions (DM 1.25), indicating that such graft copolymers possessed controlled density and distribution of side chains as its linear template. The investigation on thermal properties of the well-defined graft copolymers implied that the precise tailoring over copolymer structures at the molecule level could lead to tunable chemical/physical properties. This work bridged polymer from sequence to architecture, unveiled a new method in creating graft copolymers with programmable structures and provided the insight into the structure/property relationship.

Method for preparing 4, 10-dioxabicyclo[5.2. 1.0(2, 6)]decane-8-ene-3-ketone

-

Paragraph 0023-0025, (2020/05/30)

The invention discloses a method for preparing 4, 10-dioxabicyclo[5.2. 1.0(2, 6)]decane-8-ene-3-ketone, and belongs to the technical field of organic chemistry. Maleic anhydride is used as a raw material, and is sequentially subjected to a selective reduction reaction and a Diels-Alder reaction to obtain the 4, 10-dioxabicyclo[5.2. 1.0(2, 6)]decane-8-ene-3-ketone. According to the method, the rawmaterials are easy to obtain, the reaction conditions of each step are simple, the side reaction of polymerization of double bonds in the product can be effectively inhibited, verification is carriedout in kilogram-scale reaction or above, and the process batch reproducibility is good.

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