54260-74-1

Basic information

• Product Name: 2,3-methylenedioxy-9,10-dimethoxy-13-n-propylprotoberberine chloride
• Synonyms: 2,3-methylenedioxy-9,10-dimethoxy-13-n-propylprotoberberine chloride
• CAS NO: 54260-74-1
• Molecular Weight: 413.901
• Mol File: 54260-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-methylenedioxy-9,10-dimethoxy-13-n-propylprotoberberine chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-methylenedioxy-9,10-dimethoxy-13-n-propylprotoberberine chloride(54260-74-1)
• EPA Substance Registry System: 2,3-methylenedioxy-9,10-dimethoxy-13-n-propylprotoberberine chloride(54260-74-1)

Safety Data

• Hazardous Substances Data: 54260-74-1(Hazardous Substances Data)

Upstream product

• 483-15-8 7,8-dihydroberberine 
• 123-38-6 propionaldehyde 

Relevant articles and documents

Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: Synthesis, structure-activity relationships, and cholesterol-lowering efficacy

Twenty-nine derivatives of berberine (1) or pseudoberberine (2) were designed, semisynthesized, and evaluated for their up-regulatory activity on the low-density-lipoprotein receptor (LDLR) expression. SAR analysis revealed that (i) the methylenedioxy group at the 2- and 3-position is an essential element to keep the activity, (ii) the 7-position quaternary ammonium and planar structure of the compound are activity-required, and (iii) addition of electron-donating groups at the 7- or 13-position reduced the activity. Of the compound 1 analogues, compound 2 exhibited an increased activity on LDLR expression compared to 1.Inthe hyperlipidemic rats, compound 2 (100 (mg/kg)/day) reduced blood CHO and LDL-c by 42.6% and 49.4%, respectively, more efficient than 1 did (p 50 of 2 in mice was over 5000 mg/kg (oral). We consider compound 2 a promising cholesterol- lowering drug candidate.