54267-06-0Relevant articles and documents
NOVEL COMPOUNDS AND USES THEREOF
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Paragraph 00595, (2015/01/06)
The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of any one of Formulae (I)-(IV) and pharmaceutical compositions
Iron-porphyrin NO complexes with covalently attached N-donor ligands: Formation of a stable six-coordinate species in solution
Berto, Timothy C.,Praneeth,Goodrich, Lauren E.,Lehnert, Nicolai
experimental part, p. 17116 - 17126 (2010/03/25)
A series of substituted tetraphenylporphyrin type macrocycles (TMP or To-F2PP) with covalently attached N-donor ligands (pyridine or imidazole linker) have been synthesized. Linkers with varying chain lengths and designs have been applied to systematically investigate the effect of chain length and rigidity on the binding affinity of the linker to the corresponding Fe(II)-NO heme complexes. The binding of the linker is monitored in solution using a variety of spectroscopic methods including UV-vis absorption, EPR, and IR spectroscopy. Both the N-O stretching frequency and the imidazole 14N hyperfine coupling constants show a good correlation with the Fe-(N-donor) bond strength in these systems. The complexes with covalently attached pyridyl and alkyl imidazole ligands only exhibit weak interactions of the linker with iron(II). However, the stable six-coordinate complex [Fe(To-F2PP-BzIM)(NO)] (4) is obtained when a rigid benzyl linker is applied. This complex exhibits typical properties of six-coordinate ferrous heme-nitrosyls in which an N-donor ligand is bound trans to NO, including the Soret band at 427 nm and the typical nine line 14N hyperfine splitting in the EPR spectrum. A crystal structure has been obtained for the corresponding zinc complex. Here, we report the first systematic study on the requirements for the formation of stable six-coordinate ferrous heme nitrosyl complexes in solution at room temperature in the absence of excess axial N-donor ligand.
N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof
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Page/Page column 33, (2010/11/26)
The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds, compositions comprising an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactiv
PYRIDAZINONE COMPOUNDS AS CALCILYTICS
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Page/Page column 119, (2010/11/27)
Various calcilytic compounds and pharmaceutical compositions containing these compounds are disclosed. Calcilytic compounds are compounds capable of inhibiting calcium receptor activity. Methods for preparing calcilytic compounds, oral bioavailability of calcilytic compounds, and their use as calcium receptor antagonists are also disclosed.
Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate.
Mann, Stephane,Perez Melero, Concepcion,Hawksley, Dan,Leeper, Finian J
, p. 1732 - 1741 (2007/10/03)
3-Deazathiamin diphosphate (deazaTPP) and a second thiamin diphosphate (TPP) analogue having a benzene ring in place of the thiazolium ring have been synthesised. These compounds are both extremely potent inhibitors of pyruvate decarboxylase from Zymomonas mobilis; binding is competitive with TPP and is essentially irreversible even though no covalent linkage is formed. DeazaTPP binds approximately seven-fold faster than TPP and at least 25,000-fold more tightly (K(i) less than 14 pM). DeazaTPP is also a potent inhibitor of the E1 subunit of alpha-ketoglutarate dehydrogenase from E. coli and binds more than 70-fold faster than TPP. In this case slow reversal of the inhibition could be observed and a K(i) value of about 5 nM was calculated (ca. 500-fold tighter binding than TPP).
CERTAIN HYDROXY-PHOSPHINYL-OXY-PHENYL METHYL-THIAZOLIUM HYDROXIDE INNER SALTS AS PAF ANTAGONISTS
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, (2008/06/13)
The invention is a compound of R or S enantiomers or racemic mixtures of compounds of the formula: STR1 wherein: (A) X is (i) C 1-C 24(ii) C 1-C 24 alkoxy;(iii) C 1-C 24 carboamoyloxy; STR2 wherein n is an integer from 1 to 25 and m is
Synthesis and Characterization of Blocked and Ligand-Appended Hemes Derived from Atropisomeric meso-Diphenylporphyrins
Young, Richard,Chang, C. K.
, p. 898 - 909 (2007/10/02)
The synthesis of a series of sterically blocked and imidazole-appended meso-diphenyletioporphyrins is described.These hybrid porphyrins have good solubility and spectroscopic properties of β-substituted porphyrins as well as the orientation specificity of ortho-position-derivatized tetraphenylporphyrins.The effectiveness of the blocking groups is demonstrated by ferric hemin hydroxide formation in the doubly protected trans-5,15-bis-2,8,12,18-tetraethyl-3,7,13,17-tetramethylporphine, characterized by UV-visible, 1H NMR, and IR spectra and cyclic voltammetry.The advantage of the m-benzyl linkage in enforcing imidazole coordination to ferric hemes is demonstrated by 1H NMR studies on various type of imidazole-appended heme complexes.Several potential binucleating systems have also been prepared by incorporating nonheme chelating ligands to the hybrid porphyrins.
