5428-57-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione is used as a potential active pharmaceutical ingredient for its possible antimicrobial, antifungal, and antitumor properties. 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione's unique structure, including the biphenyl and morpholine groups, suggests it may have specific interactions with biological targets, warranting further research into its therapeutic potential.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione may be utilized as a bioactive component in the development of new pesticides or fungicides, capitalizing on its potential antimicrobial and antifungal activities. 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione's stability and solvation properties could enhance its effectiveness and environmental compatibility in agricultural applications.
Further studies are required to characterize the specific properties and applications of 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione, as its full potential in various industries is yet to be determined.

Upstream product

• 110-91-8 morpholine 
• 92-91-1 biphenyl-4-acetaldehyde 
• 2350-89-2 p-vinylbiphenyl 

Downstream Products

• 1033590-36-1 1-([1,1'-biphenyl]-4-yl)-2-morpholino-2-thioxoethanone 
• 1430835-46-3 C₂₃H₂₁NO₄S 
• 1417706-41-2 C₂₉H₂₇NO₃S 
• 1417706-38-7 C₂₈H₂₅NO₃S 
• 1393898-15-1 4-(1,1'-biphenyl-4-yl)-5-(morpholin-4-yl)-3-phenylthiophen-2(3H)-one 
• 5728-52-9 (4-biphenylyl)acetic acid 

Relevant academic research and scientific papers

Preparation method of high purity acetyl biphenyl

The invention relates to a preparation method of a high purity biphenyl acetic acid intermediate namely acetyl biphenyl (I). The preparation method is characterized in that 4-dimethylaminopyridine is taken as the catalyst, and biphenyl and acetic anhydride carry out Friedel-Crafts acylation reactions to generate acetyl biphenyl (I). The method has the advantages that 4-dimethylaminopyridine is taken as the catalyst, the obtained product purity is high, the byproducts are few, the purity can reach 99%, the refinement is not needed, and the yield is increased. The impurities are eliminated, so the impurities will not participate in the subsequent reactions and the final product will not contain the impurities. Acetyl biphenyl and morpholine carry out condensation reactions. Finally, the reaction product is saponified and acidified to obtain a crude product. The crude product is refined for once, and the purity can reach 100%. The multiple refinements are eliminated. The product better satisfies the pharmaceutical requirements. The quality of biphenyl acetic acid is improved. The cost is reduced. The total yield is increased from 63-65% to 75-80%.

Zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides: A new approach to the synthesis of amidines

The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding

Solvent-free synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents using KF-Al2O3 under microwave irradiation

The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported. Copyright Taylor & Francis Group, LLC.

Willgerodt-kindler's microwave-enhanced synthesis of thioamide derivatives

The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.

A versatile one-pot synthesis of 2,3,5-tri-substituted thiophenes from thiomorpholides

An efficient method for the preparation of 2,3,5-trisubstituted thiophenes in a one-pot synthesis from thiomorpholides via the thio-Claisen rearrangement was developed.

Microwave-assisted rapid hydrolysis and preparation of thioamides by Willgerodt-Kindler reaction

Aldehydes and aryl alkyl ketones were efficiently transformed to thioamides with the same number of carbon atoms via Willgerodt-Kindler reaction under microwave irradiation in solvent-free conditions. The thioamides obtained were hydrolyzed to corresponding carboxylic acids with microwave dielectric heating in one minute. Both reactions are very fast and the yields are excellent.

Microwave assisted Willgerodt-Kindler reaction of styrenes

Styrenes are efficiently transformed to thioamides via the Willgerodt- Kindler reaction under microwave irradiation.

Synthesis and Mesomorphic Properties of 2,6-Disubstituted Tetralins

Synthesis and mesomorphic behavior of nine members of each of the two classes of 6-phenyl- and 2-phenyltetralins and five members of the 2-trans-cyclohexyltetralins are reported.The synthesis of one member of each class is described in detail.Besides the target compounds, more than twenty intermediates showed liquid crystalline properties; their transition temperatures are recorded (see Tables 1-6).

Fenbufen, a new anti inflammatory analgesic: synthesis and structure activity relationships of analogs

100 analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti inflammatory tests and the 2 phenyl 1,4 benzoquinone writhing and inflamed paw pressure analgesic tests. Only 3 retained the same full spectrum of activity as fenbufen: dl 4 (4 biphenylyl) 4 hydroxybutyric acid, dl 4 (4 biphenylyl) 1,4 butanediol, and 4 biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the 5 tests. In addition, dose response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all 5 tests. Two related compounds were generally similar.