54295-46-4Relevant academic research and scientific papers
Cascade synthesis of 3-quinolinecarboxylic ester via benzylation/ propargylation-cyclization
Fan, Jinmin,Wan, Changfeng,Sun, Gaojun,Wang, Zhiyong
, p. 8608 - 8611 (2008)
(Chemical Equation Presented) Reactions of 2-amino-aryl alcohols with β-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation- cyclization, 2-nitrophenyl propargyl alcohols with β-ketoesters catalyzed by FeCl3 and SnCl2 also produce the 4-alkyne-3- quinolinecarboxylic esters. The mechanistic details of this benzylation/ propargylation and cyclization cascade process are also discussed.
