543-24-8Relevant articles and documents
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Schwartz,Amidon
, p. 1464,1465 (1966)
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Acyl iodides in organic synthesis: VIII. Reactions with amino acids
Voronkov,Belousova,Trukhina,Vlasova
, p. 172 - 174 (2006)
Reactions of acyl iodides RCOI (R=Me, Ph) with glycine, β-alanine, and γ-aminobutyric acid were investigated. The reaction proceeded easily at room temperature without solvent involving both functional groups H2N and COOH. The prevalence of one of the reaction directions depends on the acidity of the amino acid. The more acidic glycine (pKa, 2.4) reacts with RCOI affording mainly N-acylated product, whereas β-alanine (pK a 3.60) and especially γ-aminobutyric acid (pKa 4.06) are predominantly involved into exchange iodination furnishing the corresponding aminoacyl iodides. Pleiades Publishing, Inc. 2006.
Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media
An, Yuhao,Feng, Yuan,Hou, Zhanfeng,Jiang, Chenran,Li, Zigang,Lian, Chenshan,Sun, Jinming,Wan, Chuan,Wang, Rui,Yang, Dongyan,Yin, Feng,Zhang, Liang
supporting information, (2022/01/20)
A novel amidation strategy using electrophilic sulfonium, which is soluble and stable in aqueous conditions, was developed. The sulfoniums could activate thioacid and carboxyl acid to efficiently react with amines to afford amides. This method enables applications in amidation in both aqueous media and solid-phase peptide synthesis, peptide/protein modifications, and reactive lysines of a proteome at pH 10 with activity-based protein profiling. A peptide ligand-directed labeling of the USP7-UBL2 domain was also performed using this method.
CXCR4-TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS WITH REDUCED SPECIES SELECTIVITY
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Page/Page column 63-64, (2020/05/07)
The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.
