54303-31-0

Usage

Uses

Used in Adhesives Industry:
3-Methoxyethoxypropylamine is used as a coupling agent for improving adhesion and wetting properties in adhesive formulations, enhancing the bonding strength between different substrates.
Used in Coatings Industry:
3-Methoxyethoxypropylamine is used as a coupling agent in coatings to improve the adhesion of the coating to various surfaces, resulting in better durability and performance.
Used in Sealants Industry:
3-Methoxyethoxypropylamine is used as a coupling agent in sealants to enhance their adhesion to different materials, providing a stronger and more reliable seal.
Used as a Corrosion Inhibitor:
3-Methoxyethoxypropylamine is used as a corrosion inhibitor in various applications to protect metal surfaces from corrosion, extending the service life of the materials.
Used as an Intermediate in Chemical Synthesis:
3-Methoxyethoxypropylamine serves as an intermediate in the synthesis of other chemicals, contributing to the development of new compounds and materials with specific properties and applications.

InChI:InChI=1/C6H15NO2/c1-8-5-6-9-4-2-3-7/h2-7H2,1H3/p+1

Upstream product

• 35633-50-2 3-(2-methoxyethoxy)propanenitrile 

Downstream Products

• 200400-75-5 N-<3-(2-methoxyethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide 

Relevant academic research and scientific papers

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound 3 [UCM-1336, IC50 = 2 μM], which is selective against the other enzymes involved in the post-translational modifications of Ras. Compound 3 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, compound 3 surmounts many of the common limitations of available Ras inhibitors described so far. In addition, these results validate ICMT as a valuable target for the treatment of Ras-driven tumors.

Competitive intramolecular hydrogen bonding in oligo(ethylene oxide) substituted quadruple hydrogen bonded systems

(Figure Presented) A series of oligo(ethylene oxide) (oligoEO) substituted 2-ureido-pyrimidinones (UPy), differing in the number of ethylene oxide units and the length of the aliphatic spacer connecting the oligoEO side chain with the UPy group, have been prepared. It was found that variation in these structural parameters strongly influences the dimerization constant (K dim) of theUPy dimer and the association constant (Ka) of UPy with 2,7-diamido-1,8-naphthyridine (NaPy) in chloroform. By analyzing the relation between dimerization strength, length of aliphatic spacer, and the number of EO units in the oligoEO chain, we present strong evidence that the reduction in hydrogen bond strength is caused by competitive intramolecular hydrogen bonding of the ether atoms of the oligoEO chain to the hydrogen bond donors of the UPy unit.