54303-31-0

Basic information

• Product Name: 3-METHOXYETHOXYPROPYLAMINE
• Synonyms: 3-(2-METHOXYETHOXY)PROPAN-1-AMINE;3-(2-METHOXYETHOXY)PROPYLAMINE;3-METHOXYETHOXYPROPYLAMINE;3-(2-METHOXYETHOXY)-1-PROPANAMINE;1-Propanamine, 3-(2-methoxyethoxy)-;Einecs 259-082-3;γ-propylaMine a ethoxy;FENTAMINE OPA-ME
• CAS NO: 54303-31-0
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.19
• EINECS: 259-082-3
• Mol File: 54303-31-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 186.2°C at 760 mmHg
• Flash Point: 69.4°C
• Appearance: /
• Density: 0.925±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.671mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.71±0.10(Predicted)
• CAS DataBase Reference: 3-METHOXYETHOXYPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYETHOXYPROPYLAMINE(54303-31-0)
• EPA Substance Registry System: 3-METHOXYETHOXYPROPYLAMINE(54303-31-0)

Safety Data

• Hazardous Substances Data: 54303-31-0(Hazardous Substances Data)

Usage

General Description

3-Methoxyethoxypropylamine, also known as MEEP, is a chemical compound with the molecular formula C7H17NO2. It is an organic compound that is commonly used as a coupling agent in the production of polymers and resins. MEEP is known for its ability to improve adhesion and wetting properties in various applications, including adhesives, coatings, and sealants. It is also used as a corrosion inhibitor and as an intermediate in the synthesis of other chemicals. MEEP is a clear, colorless liquid with a faint odor, and it is considered to be relatively stable and safe to handle when used in accordance with proper handling and storage procedures.

InChI:InChI=1/C6H15NO2/c1-8-5-6-9-4-2-3-7/h2-7H2,1H3/p+1

Upstream product

• 35633-50-2 3-(2-methoxyethoxy)propanenitrile 

Downstream Products

• 200400-75-5 N-<3-(2-methoxyethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide 

Relevant articles and documents

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound 3 [UCM-1336, IC50 = 2 μM], which is selective against the other enzymes involved in the post-translational modifications of Ras. Compound 3 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, compound 3 surmounts many of the common limitations of available Ras inhibitors described so far. In addition, these results validate ICMT as a valuable target for the treatment of Ras-driven tumors.