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Upstream product

• 4547-02-8 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione 
• 22118-09-8 2-bromoacetyl chloride 
• 18091-89-9 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine 

Relevant academic research and scientific papers

Triazolobenzodiazepine derivatives

The invention relates to 1-aminomethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine compounds useful as sedatives, tranquilizers, anticonvulsants or hypnotics, and processes for their production.

1-Halomethyl-6-phenyl-4H-s-[4,3-a][1,4]benzodiazepines

1-Substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula II: STR1 wherein R0 is selected from the group consisting of hydrogen, methyl, ethyl, fluorine, chlorine, and bromine, and X is selected from fluorine, chlorine, and bromine; wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms inclusive; wherein R2, R3, R4, and R5 are selected from the group consisting of hydrogen, alkyl, as defined above, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, and alkylsulfonyl, in which the carbon chain moieties are of 1 to 3 carbon atoms, inclusive, are prepared by reacting a compound of the formula: STR2 wherein R1, R2, R3 R4, and R5 are defined as above, with an haloacyl chloride or haloacyl bromide of the formula STR3 wherein Ro and X are defined as above and X' is chlorine or bromine. The new products of formula II including their pharmacologically acceptable acid addition salts are useful as sedatives, tranquilizers and muscle relaxants in mammals and birds, and if X=X"=Cl or Br they are useful as intermediates for cyano, alkylthio and dialkylamino products of high sedative and tranquilizing activity.