54308-35-9Relevant academic research and scientific papers
DOPAMINERGIC COMPOUNDS
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, (2008/06/13)
Novel compounds of Formula (I): STR1 or pharmaceutically acceptable salts, esters and amides thereof, wherein A is O, C, CH or CH. sub.2, n is 0 or 1, and the dotted line is a single bond when A is O or CH 2 and a double bond when A is CH or when n=0, A is C and R 6 and A taken together form a nitrogen-containing heterocycle;R is hydrogen, lower alkyl or a readily cleavable group;R. sub.1 is selected from hydrogen, halogen, lower alkyl, haloalkyl and lower alkoxy;R 2 is selected from hydrogen, halogen, lower alkyl and haloalkyl or, taken together with R 8, forms a fused ring;R 3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl or, taken together with R 4, forms a spirocycloalkyl or, taken together with R 5, forms a fused cycloalkyl;R 4 is hydrogen or alkyl or, taken together with R 3, forms a spirocycloalkyl;R 5 is hydrogen or alkyl or, taken together with R 3, forms a fused cycloalkyl;R 6 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or arylalkyl or, taken together with A when A is C and when n is 0, forms a fused nitrogen-containing heterocycle or, taken together with R. sub.7 or R 8, forms a nitrogen-containing heterocycle;R. sub.7 is hydrogen or alkyl or, taken together with R 6 or R 8, forms a nitrogen-containing heterocycle;R 8 is hydrogen or alkyl or, taken together with R 6 or R 7, forms a nitrogen-containing heterocycle or, taken together with R 2, forms a fused ring, with the proviso that R 3 and R 4 cannot simultaneously both be hydrogen, are selective dopaminergic agents and are useful for treating disorders characterized by abnormal dopaminergic activity in the central or the peripheral nervous system, for example, neurological disorders such as psychoses, Parkinson's Disease, certain cardiovascular disorders and addictive behavior disorders.
