5431-31-2Relevant academic research and scientific papers
Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio under solvent-free conditions
Tang, Zhi,Jiang, Qiutao,Peng, Lifen,Xu, Xinhua,Li, Jie,Qiu, Renhua,Au, Chak-Tong
supporting information, p. 5396 - 5402 (2017/11/22)
A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans)esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as CC and CC bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.
Efficient and simple NaBH4 reduction of esters at cationic micellar surface
Das, Debapratim,Roy, Sangita,Das, Prasanta Kumar
, p. 4133 - 4136 (2007/10/03)
(Chemical Equation Presented) A simple, efficacious, and biocompatible methodology for reducing esters with sodium borohydride at an aqueous cationic micellar surface under ambient conditions has been developed. The present method holds promise for future use in selective functional group reduction and stereocontrolled alcohol synthesis.
