5432-34-8 Usage
Uses
Used in Pharmaceutical Industry:
3,8-dibromo-deuteroporphyrin IX dimethyl ester is used as an intermediate for the synthesis of Protoporphyrin IX Dimethyl Ester-d6 (P839127), which is a labeled version of Protoporphyrin IX (PPIX). PPIX is a precursor of heme and is found in all living cells in small amounts. 3,8-dibromo-deuteroporphyrin IX dimethyl ester plays a crucial role in the development of PPIX-based strategies for cancer diagnosis and treatment.
Used in Biological Research:
3,8-dibromo-deuteroporphyrin IX dimethyl ester is utilized in biological studies to investigate the role of protoporphyrin IX in various conditions such as skin photosensitivity, biliary stones, hepatobiliary damage, liver failure, and cancer. 3,8-dibromo-deuteroporphyrin IX dimethyl ester helps researchers understand the underlying mechanisms and develop targeted therapies for these conditions.
Used in Diagnostic Applications:
In the field of diagnostics, 3,8-dibromo-deuteroporphyrin IX dimethyl ester contributes to the development of PPIX-based diagnostic tools. These tools can be employed for the early detection and monitoring of various diseases, including cancer, by exploiting the unique properties of PPIX and its derivatives.
Used in Photodynamic Therapy (PDT):
3,8-dibromo-deuteroporphyrin IX dimethyl ester can be used in the development of photodynamic therapy agents. PDT is a treatment method that involves the use of light-sensitive compounds, such as porphyrins, to selectively destroy cancer cells upon exposure to light. 3,8-dibromo-deuteroporphyrin IX dimethyl ester's properties make it a potential candidate for the design of novel PDT agents with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 5432-34-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,3 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5432-34:
(6*5)+(5*4)+(4*3)+(3*2)+(2*3)+(1*4)=78
78 % 10 = 8
So 5432-34-8 is a valid CAS Registry Number.
5432-34-8Relevant academic research and scientific papers
New Syntheses and Reactions of Some Halogenated Porphyrins
Minnetian, Ohannes M.,Morris, Ian K.,Snow, Kevin M.,Smith, Kevin M.
, p. 5567 - 5574 (2007/10/02)
Efficient syntheses of 2,4-dibromo- and 2,4-diiododeuteroporphyrin IX have been carried out by treating zinc(II) 2,4-bis(chloromercurio)deuteroporphyrin IX dimethyl ester (2) with bromine or iodine.Unavoidable mesochlorination occurs when 2 is treated with chlorine and with other free-radical chlorinating agents.Regioselective meso-chlorination and peripheral (β) bromination are shown to occur from brief treatment of copper(II) deuteroperphyrin IX or β-unsubstituted a,c-biladienes with the corresponding copper(II) halide in refluxing dimethylformamide.Protoporphyrin IX has been synthesized by vinylation of 2 via ethylene/LiPdCl3 (35percent yield), with vinyl bromide and Wilkinson's catalyst (63percent), or from 2,4-dibromodeuteroporphyrin IX with ethenyltributylstannane/(Ph3P)4Pd0 (85percent).
