54344-70-6

Upstream product

• 35477-44-2 3-(2,6,6-trimethyl-1-cyclohexen-1yl)propanal 
• 14393-46-5 methyl (E)-3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylate 
• 17283-81-7 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on 

Downstream Products

• 60713-94-2 3-(2,6,6-Trimethyl-cyclohex-1-enyl)-propionyl chloride 
• 60714-02-5 3-(2',6',6'-Trimethylcyclohex-1'-en-1'-yl)-propan-1-ol-d2 
• 54344-89-7 3-(2,6,6-trimethyl-cyclohex-1-enyl)-propan-1-ol 
• 60714-08-1 3-(2',6',6'-Trimethyl-cyclohex-1'-en-1'-yl)-1-phenylpropan-1-on 
• 60714-03-6 3-(2',6',6'-Trimethylcyclohex-1'-en-1'-yl)-propanal-d1 
• 54344-72-8 2-(3-Chloro-propyl)-1,3,3-trimethyl-cyclohexene 
• 60745-30-4 2,2,6β-Trimethyl-7β-phenyl-bicyclo<4.3.0>non-9(1)-en-7α-ol 
• 1459201-82-1 5,6-dimethoxy-2-(2-(2,6,6-trimethylcyclohex-1-enyl)ethyl)benzofuran 

Relevant academic research and scientific papers

DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: A metal-free approach for one-pot esterification

A novel and efficient I2/DMSO mediated metal-free strategy is presented for the direct C-C bond cleavage of aryl-/heteroaryl- or aliphatic α-ketoaldehydes by C2-decarbonylation and C1-carbonyl oxidation to give the corresponding carboxylic acids followed by esterification in one pot, offering excellent yields in both the steps. Here, DMSO acts as the oxygen source/oxidant and this reaction works very well under both conventional heating and microwave irradiation. This is a very simple and convenient protocol.

A Concise Synthesis of rac-Ambrox via the Palladium(0)-Catalyzed Carboalkoxylation of an Allylic Ammonium Salt, as Compared to a Formaldehyde Hetero Diels–Alder Approach

Acidic cyclization of either the diethylallylamines 29b or 30, followed by a 1.5 mol-% Pd-catalyzed carbomethoxylation of quaternized 31b, leads to the methyl ester 36a. This latter could also be obtained in optically pure form by carbomethoxylation of the corresponding (+)-acetate. Final reduction-cyclization may be conducted as earlier described, towards the desired odoriferous rac-Ambrox 38a, or its pure (?)-enantiomer. Generation of a π-allyl Pd complex from an allylic ammonium salt, followed by carboalkoxylation is novel. In only five chemical steps starting from farnesene 2, the present work constitutes the most concise total synthesis of rac-Ambrox 38a to date.

BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.

A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes

The metal-free oxidation of dialkyl, alkyl aryl, or alkyl heteroaryl ketones or arylalkynes to the corresponding carboxylic acids is achieved using an oxidative mixture of Oxone and trifluoroacetic acid. This green method is a simple and mild protocol to obtain carboxylic derivatives in excellent yields.

BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF PI3K-alpha AND/OR beta

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described [formula 1] together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention. The claimed Markush formula is: [Formular 1], Y can be O, NH, NR, S; Representative compounds are: [Compounds A, B, C, D]