5435-12-1

Usage

Chemical class

Piperazine derivative

Pharmaceutical industry use

Commonly used in the development of new pharmaceutical drugs

Structural features

a. Two benzyl groups attached to the piperazine ring
b. Two methyl groups attached to the piperazine ring

Synthesis application

Often used as a building block in the synthesis of other organic compounds

Reactivity

Valuable intermediate in the creation of novel molecules with potential therapeutic properties

Research and development

May be used in research and development of new materials and other chemical applications due to its unique structure and properties

Upstream product

• 22476-74-0 3,3-dimethyl-piperazin-2-one 
• 100-44-7 benzyl chloride 
• 126458-10-4 1,4-dibenzyl-2,2-dimethyl-3-oxopiperazine 

Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationships of 5-Substituted 6,8-Difluoroquinolones, Including Sparfloxacin, a New Quinolone Antibacterial Agent with Improved Potency

A series of 5,7-disubstituted 1-cyclopropyl-6,8-difluoro-4(1H)-oxoquinoline-3-carboxylic acids (10-36) were prepared; the C-5 substituent in these compounds comprised halo, hydroxy, mercapto, and amino groups and the C-7 functional group included variously substituted piperazines.In vitro antibacterial screening results indicated that the amino group was optimal among the C-5 substituents.A combination of the C-5 amino group and the C-7 3,5-dimethylpiperazinyl appendage in this series conferred the best overall antibacterial property with lack of adverse drug interactions.Compound 36k was superior to ciprofloxacin in both in vitro and in vivo potency and hence was selected as a promising candidate for an improved therapeutic agent.