54355-51-0Relevant academic research and scientific papers
Synthesis of novel N-pyridylcantharidinimides by using high pressure
Lin, Pen-Yuan,Shi, Sheng-Jie,Lin, Lun-Huei,Chen, Hsue-Fen,Hsu, Feng-Lin
, p. 49 - 53 (2001)
The recently described pressure reaction in the presence of trithylamine with subsequent thermal (200°C) cyclization provided 13N-pyridylcantharidinimides 4a-4m from aminopyridines and cantharidin in yields of 15-83%. 2-Amino-3,5-dichloropyridine failed t
Containing chromon structure pyrromonazole Norcantharidin derivative and its preparation method and application
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Paragraph 0013; 00387, (2017/02/24)
The invention discloses a novel chromone structure-containing pyrazole norcantharidin derivative, and a preparation method and an application thereof. The preparation method comprises the following steps of: introducing a pyrazole ring to the sites C5 and C6 in the norcantharidin structure by a 1,3-dipolar cycloaddition method, and reacting the norcantharidin with the pyrazole ring with chromone derivatives to import the chromone structure to synthesize a series of total 6 novel chromone structure-containing pyrazole norcantharidin derivatives; as a result, the activity of the norcantharidin is improved. The chromone structure-containing pyrazole norcantharidin derivatives provided by the invention are applied to the synthesis of anti-tumor drugs, and have wide application prospect.
