54355-99-6Relevant articles and documents
Easy construction of furo[2,3-f]isoindole core by the IMDAV reaction between 3-(furyl)allylamines and α,β-unsaturated acid anhydrides
Zubkov, Fedor I.,Zaytsev, Vladimir P.,Mertsalov, Dmitriy F.,Nikitina, Eugenia V.,Horak, Yuriy I.,Lytvyn, Roman Z.,Homza, Yuriy V.,Obushak, Mykola D.,Dorovatovskii, Pavel V.,Khrustalev, Victor N.,Varlamov, Alexey V.
, p. 2239 - 2253 (2016/04/19)
The vinylogues of furfurylamines, easily available in two steps from furylacroleins (3-(furyl)allylamines), were studied in a tandem N-acylation/intramolecular [4+2] cycloaddition with maleic, pyrocinchonic, and citraconic anhydrides, as well as furylacry
Rare earth triflates/chlorotrimethylsilane-promoted one-pot synthesis of enals
Kagawa, Natsuko,Sasaki, Yoshiko,Sakaguchi, Shoko,Nagatomo, Ayumi,Kojima, Hideo,Toyota, Masahiro
, p. 1581 - 1585 (2016/11/07)
Some heteroaromatic aldehydes were subjected to conditions promoting the rare earth triflates/chlorotrimethylsilane-promoted one-pot synthesis of enals. As a result, diverse α,β-unsaturated aldehydes were obtained in moderate yields.
A general method for the enantioselective synthesis of α-chiral heterocycles
Le, Phong Q.,Nguyen, Thien S.,May, Jeremy A.
supporting information, p. 6104 - 6107 (2013/02/23)
The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er's are observed for a host of common heteroaryls.
Simple one-pot conversion of aldehydes and ketones to enals
Valenta, Petr,Drucker, Natalie A.,Bode, Jeffrey W.,Walsh, Patrick J.
supporting information; experimental part, p. 2117 - 2119 (2009/10/18)
A simple and efficient method to convert aldehydes into α,β-unsaturated aldehydes with a two-carbon homologation is presented. Hydroboration of ethoxy acetylene with BH3·SMe 2 generates tris(ethoxyvinyl) borane. Transmetalation with
SULFONYLPYRAZOLE AND SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS
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Page/Page column 31, (2008/06/13)
This invention concerns sulfonylpyrazoline carboxamidine derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes. The compounds have the general formula (1), wherein the symbols have the meanings given in the description.
1,4-DIHYDROPYRIDINE DERIVATIVES
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, (2008/06/13)
A 1,4-dihydropyridine derivative having the formula (I): wherein, R1represents a substituted or unsubstituted phenyl or heterocyclic group, R2represents a C1to C5lower alkyl group, R3represents a substituted or unsubstituted C2to C8alkyl, alkenyl, alkynyl or substituted or unsubstituted cycloalkyl group, R4represents -A-R5, wherein A represents a C2to C8alkylene group or a substituted or unsubstituted C2to C8alkenylene group, and R5represents a substituted or unsubstituted pyridyl, pyridylcarbonyl or piperadinyl group and a drug for overcoming resistance to an anti-cancer drug or a drug increasing the effect of an anti-cancer drug containing as an effective ingredient the derivative or its pharmacologically acceptable salt or hydrate.
Total syntheses of strychnan- and aspidospermatan-type alkaloids. 2. Generation of 15-(3-furanyl) ABCE tetracyclic intermediates
Parsons,Berk,Kuehne
, p. 7482 - 7489 (2007/10/02)
The synthesis of Nb-benzyl-2-(dimethyl 2-malonyl)- and 2-(methyl 2- acetyl)tryptamines (21, 25) provides access to methyl 4-(3-furanyl)- 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate (12) and methyl 3- benzyl-5-(3-furanyl)-2,3,3a,4,5,
FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS
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, (2008/06/13)
Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.
Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase
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, (2008/06/13)
Substituted furan and pyrrole compounds of formula (I) which are useful in inhibiting lipoxygenase enzymes, particuarly 5-lipoxygenase.