54359-58-9Relevant academic research and scientific papers
Synthesis of some new thiadiazole derivatives endowed with analgesic and anti-inflammatory activities
Pandey, Ajit K.,Kashyap, Pranita P.,Kaur, Chanchal D.,Sawarkar, Hemant A.,Singh, Mukesh K.
, p. 163 - 171 (2019/01/18)
In the present study, some new Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-N- (4-methoxybenzylidene)-4-aminophenyl-1,3,4-thiadiazole (7f) was found to have a superior analgesic and antiinflammatory profile with low gastric ulceration incidence.
Ring Transformation of 3,1-Benzothiazin-2,4-dithiones with Carboxylic Acid Hydrazides to Substituted 1,3,4-Thiadiazoles or in the Presence of Hydroxid Ions to 3-Acylamino-quinazolin-2,4-dithiones
Leistner, Siegfried,Hentschel, Karin,Wagner, Guenther
, p. 915 - 922 (2007/10/02)
The substituted 1,3,4-thiadiazoles 4-14 were prepared in one step by reaction of 3,1 benzothiazin-2,4-dithiones 1 and 3 with RCONHNH2 (R=Me, Ph, substituted Ph, 4-Pyridyl, CONHNH2).Reaction of 1 with RCONHNH2 in the presence of HO(-) leads to substituted quinazolin-2,4-dithiones 18-20.Under the action of CS2 the yield of 19 and 20 increases.Possible reaction mechanisms are discussed. - keywords: 2H-3,1-Benzothiazin-2,4(1H)-dithione; Carbocyclic acid hydrazides; Quinazolin-2,4(1H,3H)-dithione; Ring transformation; 1,3,4-Thiadiazoles
