5436-03-3

Usage

Uses

Used in Organic Synthesis:
2-(bromomethyl)-4,5-diphenyl-1,3-dioxolane is used as a reagent and intermediate in the production of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structural properties and functional groups contribute to its versatility in organic synthesis.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-(bromomethyl)-4,5-diphenyl-1,3-dioxolane is used as a key component in the development of new drugs. Its potential applications in drug discovery and design are attributed to its ability to be modified and incorporated into diverse molecular frameworks, enhancing the therapeutic potential of resulting compounds.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 2-(bromomethyl)-4,5-diphenyl-1,3-dioxolane is utilized as a reagent and intermediate for the synthesis of various agrochemicals. Its functional groups and structural features allow for the creation of novel agrochemicals with improved efficacy and selectivity.
Safety Precautions:
It is crucial to handle 2-(bromomethyl)-4,5-diphenyl-1,3-dioxolane with proper safety measures due to its potential reactivity and toxicity. Adequate protective equipment and handling procedures should be followed to minimize risks associated with its use in research and industrial applications.

InChI:InChI=1/C16H15BrO2/c17-11-14-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-10,14-16H,11H2

Upstream product

• 579-43-1 (1S,2R)-1,2-diphenylethane-1,2-diol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 138886-49-4 4,4a-dihydro-4',5'-diphenylspiro<3H,10H-pyrano<4,3-b><1>benzopyran-3,2'-<1,3>dioxolan>-10-one 
• 655-48-1 DL-1,2-diphenylethane-1,2-diol 

Downstream Products

• 129381-41-5 2-Methylene-4,5-diphenyl-1,3-dioxolane 
• 138886-49-4 4,4a-dihydro-4',5'-diphenylspiro<3H,10H-pyrano<4,3-b><1>benzopyran-3,2'-<1,3>dioxolan>-10-one 
• 138886-49-4 4,4a-dihydro-4',5'-diphenylspiro<3H,10H-pyrano<4,3-b><1>benzopyran-3,2'-<1,3>dioxolan>-10-one 
• 129381-41-5 trans-2-methylene-4,5-diphenyl-1,3-dioxolane 

Relevant academic research and scientific papers

Heterodiene cycloadditoins of C2 symmetric 4,5-disubstituted ketene acetals: the nett asymmetric conjugate addition of recyclable acetic ester enolate equivalents to an activated enone

Heterodiene cycloadditions of 3-formylchromone 2 to a series of ketene acetals 1 derived from C2 symmetric 1,2-diarylethane-1,2-diols are diastereoselective.From (S,S)-1,2-di(o-tolyl)ethane-1,2-diol 6c the major cycloadduct 3c was isolated by crystallization and transformed by acid-catalysed methanolysis into (S)-methyl 4-oxo-3,4-dihydro-2H-1-benzopyran-2-ylacetate 5, together with the original 1,2-diol 6c which could be recycled.The structures of two cyclic carbonates 22a and 22c were determined by X-ray diffraction and used as models in seeking a mechanistic rationale for the stereoselective cycloadditions of the analogous ketene acetals 1a and 1c.

Preparation of racemic and enantiomerically pure cyclic ketene acetals

Cyclic ketene acetals have been prepared from a-haloaldehyde dimethylacetals by transacetalization and subsequent elimination in PTC without solvent conditions. No racemization has been observed when an enantiomerically pure diol has been used. Stability and storage conditions have been studies.

Nett Asymmetric Conjugate Addition of a Recyclable Acetic Ester Enolate Equivalent

Heterodiene cycloadditions of 3-formyl chromone to ketene acetals derived from C2-symmetric 1,2-diarylethane-1,2-diols are diastereoselective; methanolysis of the cycloadducts derived from (S,S)-hydrobenzoin releases optically enriched methyl 3,4-dihydro-4-oxo-2H-1-benzopyran-2-ylacetate and the optically pure 1,2-diol.