5437-39-8

Usage

InChI:InChI=1/C8H14NO6/c1-8(9(14)15,4-2-6(10)11)5-3-7(12)13/h14H,2-5H2,1H3,(H,10,11)(H,12,13)/q-1

Upstream product

• 10499-89-5 dimethyl 4-methyl-4-nitroheptanedioate 
• 60769-60-0 diethyl 4-methyl-4-nitroheptanedioate 
• 220593-27-1 di-tert-butyl 4-nitro-4-methylheptanedicarboxylate 

Relevant academic research and scientific papers

VALENCY DEPENDENT BIOACTIVE HYDROXYAPATITE-BINDING DENDRONS

The present invention is generally directed a series of novel multivalent, HA-binding peptide bioconjugates with variable dendron valency and tether length, which afford the ability to precisely tune the desired binding behavior, as well as related methods and uses. Certain of these novel multivalent, HA-binding peptide bioconjugates have been found to have a 300-fold increase in binding affinity compared to HA-binding peptide sequences reported previously.

COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS

The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease,