5437-60-5

Basic information

• Product Name: 2-Bromo-2-nitroethanol
• Synonyms: 2-Bromo-2-nitroethanol
• CAS NO: 5437-60-5
• Molecular Formula: C₂H₄BrNO₃
• Molecular Weight: 169.96
• Mol File: 5437-60-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 243.8°Cat760mmHg
• Flash Point: 101.2°C
• Appearance: /
• Density: 1.99g/cm³
• Vapor Pressure: 0.00532mmHg at 25°C
• Refractive Index: 1.534
• PKA: 2.86±0.36(Predicted)
• CAS DataBase Reference: 2-Bromo-2-nitroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-2-nitroethanol(5437-60-5)
• EPA Substance Registry System: 2-Bromo-2-nitroethanol(5437-60-5)

Safety Data

• Hazardous Substances Data: 5437-60-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-2-nitroethanol (C2H4BrNO3) is an organic compound defined by the presence of bromo, nitro, and alcohol functional groups. Its molecular weight is 187.97 g/mol. It is a brominated derivative of nitroethanol, a compound that finds usage in several applications due to its chemical reactivity. With its introduction into other compounds, 2-Bromo-2-nitroethanol can affect physical and chemical properties, including volatility, melting point, and polarity. Its risk and safety information is crucial for its handling and storage. Much like various other nitro compounds, it is not recommended for ingestion or inhalation due to probable adverse health effects.

InChI:InChI=1/C2H4BrNO3/c3-2(1-5)4(6)7/h2,5H,1H2

Upstream product

• 50-00-0 formaldehyd 
• 563-70-2 bromonitromethane 
• 52-51-7 2-bromo-2-nitro-1,3-propanediol 
• 119276-81-2 2-nitro-ethanol; monosodium salt 
• 625-48-9 2-nitro-1-ethanol 

Downstream Products

• 625-48-9 2-nitro-1-ethanol 
• 69094-18-4 2,2-dibromo-2-nitro-1-ethanol 
• 98280-59-2 1-bromo-2-(1-ethoxy-ethoxy)-1-nitro-ethane 
• 89033-68-1 acetic acid-(2-bromo-2-nitro-ethyl ester) 
• 29609-98-1 2,2-dinitroethanol 

Relevant articles and documents

Synthetic method for (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol

The invention belongs to the technical field of synthesis of a florfenicol intermediate and particularly relates to a synthetic method for (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol. The method comprises the following steps that a sodium hydroxide water solution is added into 2-nitro ethyl alcohol in a dripped mode, then bromine is added, and the reaction is carried out to obtain 2-bromine-2-nitro ethyl alcohol; 2-bromine-2-nitro ethyl alcohol and ethyl alcohol are obtained, a hydrogenation catalyst is added, the mixture reacts with hydrogen, alcohols solvent is added, and then dichloroacetonitrile is added in a dripped mode for reaction; magnesium, tetrahydrofuran and 4- methylsulfonyl benzaldehyde are added to obtain a ring compound II; the ring compound II is subjected to an isomerization reaction in the alcohols solvent to obtain (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol. According to the method, a brand-new synthetic route is adopted, and generation of a large amount of copper-containing wastewater difficult to treat is avoided; hydrogen is adopted for reduction, generation of a large number of three wastes is avoided, cost is reduced, the total yield is high and is over 98%, benefits are increased, and environment is protected.