5437-60-5

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-2-nitroethanol is used as a chemical intermediate for the synthesis of various organic compounds. Its reactivity allows it to be a key component in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
In the field of research, 2-Bromo-2-nitroethanol is used as a reagent in the development of new chemical reactions and processes. Its unique properties make it a valuable tool for studying reaction mechanisms and exploring new synthetic pathways.
Used in Material Science:
2-Bromo-2-nitroethanol is used as a component in the formulation of new materials with specific properties. Its ability to modify the physical and chemical characteristics of other compounds can lead to the creation of materials with tailored properties for various applications, such as in electronics or coatings.
Used in Safety and Risk Assessment:
Understanding the risk and safety profile of 2-Bromo-2-nitroethanol is crucial for its safe handling, storage, and disposal. It is used in the development of safety protocols and risk assessments to ensure the protection of workers and the environment from potential hazards associated with its use.

InChI:InChI=1/C2H4BrNO3/c3-2(1-5)4(6)7/h2,5H,1H2

Upstream product

• 625-48-9 2-nitro-1-ethanol 
• 52-51-7 2-bromo-2-nitro-1,3-propanediol 
• 119276-81-2 2-nitro-ethanol; monosodium salt 
• 50-00-0 formaldehyd 
• 563-70-2 bromonitromethane 

Downstream Products

• 29609-98-1 2,2-dinitroethanol 
• 625-48-9 2-nitro-1-ethanol 
• 98280-59-2 1-bromo-2-(1-ethoxy-ethoxy)-1-nitro-ethane 
• 69094-18-4 2,2-dibromo-2-nitro-1-ethanol 
• 89033-68-1 acetic acid-(2-bromo-2-nitro-ethyl ester) 

Relevant academic research and scientific papers

Synthetic method for (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol

The invention belongs to the technical field of synthesis of a florfenicol intermediate and particularly relates to a synthetic method for (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol. The method comprises the following steps that a sodium hydroxide water solution is added into 2-nitro ethyl alcohol in a dripped mode, then bromine is added, and the reaction is carried out to obtain 2-bromine-2-nitro ethyl alcohol; 2-bromine-2-nitro ethyl alcohol and ethyl alcohol are obtained, a hydrogenation catalyst is added, the mixture reacts with hydrogen, alcohols solvent is added, and then dichloroacetonitrile is added in a dripped mode for reaction; magnesium, tetrahydrofuran and 4- methylsulfonyl benzaldehyde are added to obtain a ring compound II; the ring compound II is subjected to an isomerization reaction in the alcohols solvent to obtain (4R,5R)-2-bischloromethyl-4,5-dihydro-5-(4-methylsulfonyl)-4-oxazole methyl alcohol. According to the method, a brand-new synthetic route is adopted, and generation of a large amount of copper-containing wastewater difficult to treat is avoided; hydrogen is adopted for reduction, generation of a large number of three wastes is avoided, cost is reduced, the total yield is high and is over 98%, benefits are increased, and environment is protected.

The Reaction of Geminal Bromonitroalkanes with Nucleophiles. Part 1. The Decomposition of 2-Bromo-2-nitropropane-1,3-diol (Bronopol) in Aqueous Base

2-Bromo-2-nitropropane-1,3-diol decomposes in aqueous base to give tris(hydroxymethyl)nitromethane, glycolic acid, formic acid, methanol and 2,2-dinitroethanol.It also releases NO2(1-) and Br- ions but not BrO-. these products are shown to form via four concurrent decompostion pathways, three of which involve 2-bromo-2-nitroethanol as a reactive intermediate.