5437-87-6

Usage

Type of compound

Amino-alcohol

Structural feature

Double bond in the third carbon position

Usage

Reactant in organic synthesis

Application

Building block in the production of pharmaceuticals and agrochemicals

Physical state

Colorless liquid

Odor

Strong, unpleasant

Hazardous nature

Yes, considered a hazardous substance

Health hazards

Skin and eye irritation, respiratory issues upon inhalation

Combustibility

Combustible

Safety precautions

Handle with care in a well-ventilated area

Upstream product

• 930-22-3 epoxybutene 
• 125582-78-7 C₁₀H₂₅NPb 
• 7045-86-5 2-methyl-4,7-dihydro-1,3-dioxepine 

Relevant academic research and scientific papers

Catalyzed reaction of 2-methyl-1,3-dioxep-4-ene and halogen magnesium salts of secondary amines. A new approach to allylaminoalcohols

In the presence of a catalytic amount of Ni°, 2-methyl-1,3-dioxep-4-ene (1) reacts with secondary halogen magnesioamides (2) to give mixtures of 4-aminobut-2-enols (3) and 2-aminobut-3-enols (4), arising from α- or γ-substitution to 1. The stereo and regiochemistry of the reaction is closely related to the structures of 2.

AMINOLEAD COMPOUNDS AS A NEW REAGENT FOR REGIOSELECTIVE RING OPENING OF EPOXIDES

Regioselective ring opening of epoxides is accomplished by using aminolead compounds; the reagents attack the less hindered carbon of epoxide ring, and the amino alcohols are obtained in good yields.