5438-64-2

Usage

Natural Occurrence

Found in plants like soybeans, fava beans, and kudzu

Classification

Isoflavone class of flavonoids

Potential Benefits

Phytoestrogen, antioxidant, anti-inflammatory, and anticancer properties

Health Effects

Inhibits the growth of various cancer cells, protective effects against cardiovascular diseases and osteoporosis

Medical Research

Being investigated for its potential role in hormone replacement therapy and menopausal symptom management

Limitations

More research is needed to fully understand its mechanisms and potential health benefits.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 121-33-5 vanillin 
• 25205-49-6 2′,4-dihydroxy-3-methoxychalcone 
• 104236-73-9 (2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 

Downstream Products

• 1206902-70-6 C₁₇H₁₃F₃O₆S 
• 1386981-04-9 2-methoxy-4-(4-oxochroman-2-yl)phenyl phenylcarbamate 

Relevant academic research and scientific papers

Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools

Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He

Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents

This study was designed to synthesize and evaluate flavanone derivatives with phenylcarbamate moiety as potent acetylcholinesterase (AChE) inhibitors and anti-amnestic agents for management of AD. The synthesis of carbamate-substituted flavanone derivativ

Silica supported-double metal cyanides (DMCs): A green and highly efficient catalytic protocol for isomerisation of 2′-hydroxychalcones to flavanones

Four different double metal cyanides (NiHCFe, CrHCFe, MnHCFe and ZnHCFe) were synthesized, followed by adsorbed on silica gel and used as Lewis acid catalyst in the isomerisation of substituted 2′-hydroxychalcones to flavanones under solvent-free (dry) condition. Optimization of the reaction condition, temperature effects, DMC catalysts loading and re-useable catalytic activity were further studied during the reaction. Among these catalysts, NiHCFe at 35 mol% loading gave excellent yield (90%) at 100 C temperature in 1.15 h. Catalyst (NiHCFe) easily recovered and re-used six times without much loss of its catalytic activity which gave 80-85% product yields each time. However, these DMCs were failed to give product in the solution phase even prolonging the reaction time at reflux temperature. Similarly, isomerization of substituted 2′-aminochalcones gave 2-5% yields either in solution phase or under solvent-free condition.

Synthesis of dihydrodehydrodiconiferyl alcohol: The revised structure of lawsonicin

Structural revision of lawsonicin, a natural product of Lawsonia alba, is reported based upon comparison of its spectral data with that of the naturally occurring dihydrobenzo[b]furan neolignan (rac)-trans-dihydrodehydrodiconiferyl alcohol, which is found to be identical. A concise synthesis of dihydrodehydrodiconiferyl alcohol, via Rh2[S-DOSP]4-catalysed intramolecular C-H insertion, is described. 10.1039/b918179b The Royal Society of Chemistry 2010.