54381-10-1

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 591-27-5 m-Hydroxyaniline 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 76039-71-9 2-amino-3'-hydroxydiphenylamine 

Relevant academic research and scientific papers

Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI50 = 0.71–2.41 μM against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 μM against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 μM). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Further studies on the cyclisation of 3-hydroxy-2'-nitrodiphenyl ethers and related compounds

The reductive cyclisation of 4,6-dimethyl and 4,6-dichloro derivatives of 3-hydroxy-2'-nitrodiphenyl ethers has been examined as a potential route to 1H-phenoxazinones. Unexpectedly, cyclisation of the dichloro compound proceeded with loss of a Cl and yielded 2-chloro-3H-phenoxazin-3-one. The cyclisation of a range of analogous substrates has been investigated and shown to provide novel and convenient syntheses of 3-amino-phenoxazine, 3H-phenothiazin-3-one and 8-hydroxy-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one.

Hair dye compositions containing nitrodiphenylamine dyes and method for dyeing hair therewith

A hair dye composition comprising a fluid direct-dye hair dye vehicle suitable for application to human hair containing a tinctorially effective amount of a hair dye of formula: SPC1 In which: A. R is an electron donor functional group; B. y is a whole number from 0 to 1 inclusive; and C. x is a whole number from 1 to 2 inclusive. Also describes a method of dyeing hair using these compositions and further describes certain novel nitrodiphenylamine dyes.